Rapid in vitro evolution of flucytosine resistance in Candida auris

Rapid in vitro evolution of flucytosine resistance in Candida auris

ABSTRACT The pan-antifungal-resistant pathogen Candida auris has been causing high-mortality infection outbreaks in hospitals and healthcare settings. The prodrug 5-fluorocytosine (5FC) is one of four chemical entities, but its clinical use as an antifungal drug has been limited owing to pronounced...

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Main Authors: Trinh Phan-Canh, Duc-Minh Nguyen-Le, Phuc-Loi Luu, Narakorn Khunweeraphong, Karl Kuchler
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mSphere
Subjects:
Candida auris
flucytosine
5FC
drug resistance
evolution
FCY2
Online Access:https://journals.asm.org/doi/10.1128/msphere.00977-24
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