Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease
Abstract Background and objectives Maintenance hemodialysis (MHD) patients are at a higher risk of cardiovascular disease (CVD), a common complication and leading cause of death. Persistent micro-inflammation is a unique feature of MHD. Given the established role of inflammation in the pathogenesis...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-024-02117-7 |
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| author | Xi-xi Han Hui-ying Zhang Jing-wen Kong Yu-xin Liu Ke-ren Zhang Wen-ying Ren |
| author_facet | Xi-xi Han Hui-ying Zhang Jing-wen Kong Yu-xin Liu Ke-ren Zhang Wen-ying Ren |
| author_sort | Xi-xi Han |
| collection | DOAJ |
| description | Abstract Background and objectives Maintenance hemodialysis (MHD) patients are at a higher risk of cardiovascular disease (CVD), a common complication and leading cause of death. Persistent micro-inflammation is a unique feature of MHD. Given the established role of inflammation in the pathogenesis of atherosclerosis, this study aims to explore whether novel inflammatory markers (inflammation index) can serve as independent risk factors for CVD in MHD patients. Methods A cross-sectional survey was conducted on patients from three dialysis centers, categorized into a CVD and non-CVD group based on medical history, laboratory tests, and physical examination. Fasting blood samples were collected from all participants for indicator testing. Results The analysis of 209 patients revealed that 104 had concurrent CVD. Patients in the CVD group were significantly older and exhibited higher anxiety and depression scores. Forward stepwise multivariate logistic regression results identified the inflammation index neutrophil-to-lymphocyte ratio (NLR) (OR = 1.27, 95% CI 1.082–1.491, P < 0.05) and systemic immune-inflammation index (SII) (OR = 1.001, 95% CI 1.0001–1.002, P < 0.05) as independent risk factors for CVD in MHD patients. Receiver operating characteristic (ROC) curve analysis demonstrated that SII, platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and NLR all possess predictive diagnostic values for CVD events in this patient population. Conclusions Hemodialysis centers can utilize simple and cost-effective inflammatory markers to proactively identify patients at risk of CVD. Future research into how inflammation contributes to CVD in MHD is required. |
| format | Article |
| id | doaj-art-0c0338bb508f46f99b6a952156c6e9ac |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-0c0338bb508f46f99b6a952156c6e9ac2024-11-17T12:16:28ZengBMCEuropean Journal of Medical Research2047-783X2024-11-012911910.1186/s40001-024-02117-7Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular diseaseXi-xi Han0Hui-ying Zhang1Jing-wen Kong2Yu-xin Liu3Ke-ren Zhang4Wen-ying Ren5Nephrology Department, Beijing Integrated Traditional Chinese and Western Medicine HospitalNephrology Department, Beijing Integrated Traditional Chinese and Western Medicine HospitalNephrology Department, Beijing Integrated Traditional Chinese and Western Medicine HospitalNephrology Department, Beijing Integrated Traditional Chinese and Western Medicine HospitalNephrology Department, Beijing Integrated Traditional Chinese and Western Medicine HospitalDongzhimen Hospital, Beijing University of Chinese MedicineAbstract Background and objectives Maintenance hemodialysis (MHD) patients are at a higher risk of cardiovascular disease (CVD), a common complication and leading cause of death. Persistent micro-inflammation is a unique feature of MHD. Given the established role of inflammation in the pathogenesis of atherosclerosis, this study aims to explore whether novel inflammatory markers (inflammation index) can serve as independent risk factors for CVD in MHD patients. Methods A cross-sectional survey was conducted on patients from three dialysis centers, categorized into a CVD and non-CVD group based on medical history, laboratory tests, and physical examination. Fasting blood samples were collected from all participants for indicator testing. Results The analysis of 209 patients revealed that 104 had concurrent CVD. Patients in the CVD group were significantly older and exhibited higher anxiety and depression scores. Forward stepwise multivariate logistic regression results identified the inflammation index neutrophil-to-lymphocyte ratio (NLR) (OR = 1.27, 95% CI 1.082–1.491, P < 0.05) and systemic immune-inflammation index (SII) (OR = 1.001, 95% CI 1.0001–1.002, P < 0.05) as independent risk factors for CVD in MHD patients. Receiver operating characteristic (ROC) curve analysis demonstrated that SII, platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and NLR all possess predictive diagnostic values for CVD events in this patient population. Conclusions Hemodialysis centers can utilize simple and cost-effective inflammatory markers to proactively identify patients at risk of CVD. Future research into how inflammation contributes to CVD in MHD is required.https://doi.org/10.1186/s40001-024-02117-7Maintenance hemodialysisUremiaCardiovascular diseaseInflammation indexChronic micro-inflammation |
| spellingShingle | Xi-xi Han Hui-ying Zhang Jing-wen Kong Yu-xin Liu Ke-ren Zhang Wen-ying Ren Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease European Journal of Medical Research Maintenance hemodialysis Uremia Cardiovascular disease Inflammation index Chronic micro-inflammation |
| title | Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease |
| title_full | Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease |
| title_fullStr | Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease |
| title_full_unstemmed | Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease |
| title_short | Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease |
| title_sort | inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease |
| topic | Maintenance hemodialysis Uremia Cardiovascular disease Inflammation index Chronic micro-inflammation |
| url | https://doi.org/10.1186/s40001-024-02117-7 |
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