Effect of Continuous Intake of <i>Lactobacillus salivarius</i> WB21 on Tissues Surrounding Implants: A Double-Blind Randomized Clinical Trial
Objective: This study aimed to improve the health of peri-implant tissues through continuous intake of <i>Lactobacillus salivarius</i> WB21 (LSWB21) tablets. Methods: A double-blind, randomized controlled trial was conducted with 23 maintenance patients who had generally healthy oral per...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/14/12/1532 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846103905839087616 |
|---|---|
| author | Yusuke Taniguchi Nao Suzuki Kae Kakura Kazunari Tanabe Ryutaro Ito Tadahiro Kashiwamura Akie Fujimoto Marie Naito Masahiro Yoneda Takashi Hanioka Hirofumi Kido |
| author_facet | Yusuke Taniguchi Nao Suzuki Kae Kakura Kazunari Tanabe Ryutaro Ito Tadahiro Kashiwamura Akie Fujimoto Marie Naito Masahiro Yoneda Takashi Hanioka Hirofumi Kido |
| author_sort | Yusuke Taniguchi |
| collection | DOAJ |
| description | Objective: This study aimed to improve the health of peri-implant tissues through continuous intake of <i>Lactobacillus salivarius</i> WB21 (LSWB21) tablets. Methods: A double-blind, randomized controlled trial was conducted with 23 maintenance patients who had generally healthy oral peri-implant tissues. Participants were divided into a test group (<i>n</i> = 12) receiving LSWB21 tablets and a control group (<i>n</i> = 11) receiving placebos. All patients took one tablet three times daily for 2 months. Evaluation measures included modified Gingival Index (mGI), modified Plaque Index (mPI), modified Bleeding Index (mBI), salivary secretory IgA, and oral symptoms assessed at baseline, 1 month, and 2 months. Results: After 2 months, significant improvements in the mGI, mPI, and mBI were observed in the test group; significant improvement in the mPI was observed in the control group. Changes in the mGI over 2 months significantly differed between the groups (<i>p</i> = 0.038), and multiple regression analysis confirmed the effectiveness of LSWB21 in reducing the mGI (<i>p</i> = 0.034). Subjective symptoms such as bad breath in the test group and tongue symptoms in the control group also significantly improved. Conclusion: Continuous intake of LSWB21 may be beneficial for stabilizing peri-implant tissue. Trial registration: UMIN000039392 (UMIN-CTR). |
| format | Article |
| id | doaj-art-0bf9e346a1ca4cd4a86fb027390b6fd8 |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-0bf9e346a1ca4cd4a86fb027390b6fd82024-12-27T14:35:49ZengMDPI AGLife2075-17292024-11-011412153210.3390/life14121532Effect of Continuous Intake of <i>Lactobacillus salivarius</i> WB21 on Tissues Surrounding Implants: A Double-Blind Randomized Clinical TrialYusuke Taniguchi0Nao Suzuki1Kae Kakura2Kazunari Tanabe3Ryutaro Ito4Tadahiro Kashiwamura5Akie Fujimoto6Marie Naito7Masahiro Yoneda8Takashi Hanioka9Hirofumi Kido10Section of Oral Implantology, Department of Oral Rehabilitation, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanDepartment of Preventive and Public Health Dentistry, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanSection of Oral Implantology, Department of Oral Rehabilitation, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanTanabe Preservative Dentistry, 2-12-18 Mizutani, Higashi-ku, Fukuoka 813-0031, JapanSection of Oral Implantology, Department of Oral Rehabilitation, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanSection of Oral Implantology, Department of Oral Rehabilitation, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanDepartment of Preventive and Public Health Dentistry, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanDepartment of Preventive and Public Health Dentistry, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanSection of General Dentistry, Department of General Dentistry, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanDepartment of Preventive and Public Health Dentistry, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanSection of Oral Implantology, Department of Oral Rehabilitation, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, JapanObjective: This study aimed to improve the health of peri-implant tissues through continuous intake of <i>Lactobacillus salivarius</i> WB21 (LSWB21) tablets. Methods: A double-blind, randomized controlled trial was conducted with 23 maintenance patients who had generally healthy oral peri-implant tissues. Participants were divided into a test group (<i>n</i> = 12) receiving LSWB21 tablets and a control group (<i>n</i> = 11) receiving placebos. All patients took one tablet three times daily for 2 months. Evaluation measures included modified Gingival Index (mGI), modified Plaque Index (mPI), modified Bleeding Index (mBI), salivary secretory IgA, and oral symptoms assessed at baseline, 1 month, and 2 months. Results: After 2 months, significant improvements in the mGI, mPI, and mBI were observed in the test group; significant improvement in the mPI was observed in the control group. Changes in the mGI over 2 months significantly differed between the groups (<i>p</i> = 0.038), and multiple regression analysis confirmed the effectiveness of LSWB21 in reducing the mGI (<i>p</i> = 0.034). Subjective symptoms such as bad breath in the test group and tongue symptoms in the control group also significantly improved. Conclusion: Continuous intake of LSWB21 may be beneficial for stabilizing peri-implant tissue. Trial registration: UMIN000039392 (UMIN-CTR).https://www.mdpi.com/2075-1729/14/12/1532<i>Lactobacillus salivarius</i>periimplantitisprobioticsrandomized controlled trial |
| spellingShingle | Yusuke Taniguchi Nao Suzuki Kae Kakura Kazunari Tanabe Ryutaro Ito Tadahiro Kashiwamura Akie Fujimoto Marie Naito Masahiro Yoneda Takashi Hanioka Hirofumi Kido Effect of Continuous Intake of <i>Lactobacillus salivarius</i> WB21 on Tissues Surrounding Implants: A Double-Blind Randomized Clinical Trial Life <i>Lactobacillus salivarius</i> periimplantitis probiotics randomized controlled trial |
| title | Effect of Continuous Intake of <i>Lactobacillus salivarius</i> WB21 on Tissues Surrounding Implants: A Double-Blind Randomized Clinical Trial |
| title_full | Effect of Continuous Intake of <i>Lactobacillus salivarius</i> WB21 on Tissues Surrounding Implants: A Double-Blind Randomized Clinical Trial |
| title_fullStr | Effect of Continuous Intake of <i>Lactobacillus salivarius</i> WB21 on Tissues Surrounding Implants: A Double-Blind Randomized Clinical Trial |
| title_full_unstemmed | Effect of Continuous Intake of <i>Lactobacillus salivarius</i> WB21 on Tissues Surrounding Implants: A Double-Blind Randomized Clinical Trial |
| title_short | Effect of Continuous Intake of <i>Lactobacillus salivarius</i> WB21 on Tissues Surrounding Implants: A Double-Blind Randomized Clinical Trial |
| title_sort | effect of continuous intake of i lactobacillus salivarius i wb21 on tissues surrounding implants a double blind randomized clinical trial |
| topic | <i>Lactobacillus salivarius</i> periimplantitis probiotics randomized controlled trial |
| url | https://www.mdpi.com/2075-1729/14/12/1532 |
| work_keys_str_mv | AT yusuketaniguchi effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT naosuzuki effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT kaekakura effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT kazunaritanabe effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT ryutaroito effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT tadahirokashiwamura effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT akiefujimoto effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT marienaito effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT masahiroyoneda effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT takashihanioka effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial AT hirofumikido effectofcontinuousintakeofilactobacillussalivariusiwb21ontissuessurroundingimplantsadoubleblindrandomizedclinicaltrial |