Overexpression of SOX4 in MSCs inhibits cellular senescence and enhances therapeutic efficacy in systemic lupus erythematosus

Overexpression of SOX4 in MSCs inhibits cellular senescence and enhances therapeutic efficacy in systemic lupus erythematosus

Abstract Background Mesenchymal stem cells (MSCs) are widely used in treating autoimmune diseases. However, replicative senescence limits the quantity and quality of MSCs during population doublings in vitro. Transcription factor SOX4 is a crucial regulator of cell fate and stemness. This study aims...

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Bibliographic Details
Main Authors: Jingjing Qi, Xiangge Zhao, Xiaoyu Gao, Xiaolu Zhu, Junli Wang, Jiaqing Liu, Jing Wei, Xia Li, Bihu Gao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
MSCs
Senescence
SOX4
Systemic lupus erythematosus
Online Access:https://doi.org/10.1186/s13287-025-04525-w
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