Transcriptome analysis of liver injury of fatty liver disease induced by ALDH2 deficiency

Transcriptome analysis of liver injury of fatty liver disease induced by ALDH2 deficiency

Abstract Aldehyde dehydrogenase 2 (Aldh2) Glu504Lys mutation, common in East Asians, is linked to various alcohol-related pathologies, notably fatty liver disease. Recent findings suggest that high ethanol-producing Klebsiella pneumoniae(HiAlc Kpn) exacerbates liver injury in non-alcoholic fatty liv...

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Bibliographic Details
Main Authors: Ziying Xu, Yagang Gao, Zihui Yu, Rui Zhang, Ruikun Wang, Shang Li, Shuowen Wang, Bing Du, Ziyan Tian, Lijuan Huang, Zanbo Ding, Jing Yuan
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
ALDH2 deficiency
Fatty liver disease
DEGs
HiAlc Kpn
Ethanol
Online Access:https://doi.org/10.1038/s41598-025-86547-1
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