Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function
[Objective] To analyze the production of platelet antibodies in children with congenital heart disease, identify the types of antibodies, and explore their effects on platelet count, coagulation function and platelet function. [Methods] A retrospective analysis was conducted on 3 504 congenital hear...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2024-12-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.12.008&lang=en |
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| _version_ | 1841557817521078272 |
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| author | ZHEN Zida FU Xiaoyan ZHANG Huimin LIU Yu MA Shuxuan |
| author_facet | ZHEN Zida FU Xiaoyan ZHANG Huimin LIU Yu MA Shuxuan |
| author_sort | ZHEN Zida |
| collection | DOAJ |
| description | [Objective] To analyze the production of platelet antibodies in children with congenital heart disease, identify the types of antibodies, and explore their effects on platelet count, coagulation function and platelet function. [Methods] A retrospective analysis was conducted on 3 504 congenital heart disease patients without a history of blood transfusion who were treated at Beijing Children's Hospital between January 2019 and June 2024 to study the positive rate of platelet antibodies. Platelet antibody types were detected using the solid-phase agglutination method, and the platelet count and coagulation function of the children were analyzed. The impact of platelet antibodies on platelet function was evaluated using a coagulation and platelet function analyzer. [Results] The positive rate of platelet antibody in children with congenital heart disease with no history of blood transfusion was 9.7% (341/3 504), higher than the overall positive rate of 6.6% (2 657/40 311) in the general pediatric population. The platelet antibodies in congenital heart disease cases with positive platelet antibodies were mainly autoantibodies. There was no significant difference in platelet count between antibody-positive children and antibody-negative children. However, the prothrombin time (s) of antibody-positive children was significantly longer than that of antibody-negative children[(12.19±1.07) vs (11.32±0.77)]. Platelets sensitized by antibodies showed a significant reduction in function compared to non-sensitized platelets. [Conclusion] Children with congenital heart disease have a high rate of positivity for autoantibodies, which are associated with abnormalities in coagulation function and can lead to reduced platelet function. |
| format | Article |
| id | doaj-art-0bc159c7f58749bfaa3e0ecfc532d3d6 |
| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-0bc159c7f58749bfaa3e0ecfc532d3d62025-01-06T09:43:02ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2024-12-0137121388139310.13303/j.cjbt.issn.1004-549x.2024.12.0081004-549X(2024)12-1388-06Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet functionZHEN Zida0FU Xiaoyan1ZHANG Huimin2LIU Yu3MA Shuxuan4Capital Medical University Affiliated Beijing Children's Hospital, Beijing 100045, ChinaCapital Medical University Affiliated Beijing Children's Hospital, Beijing 100045, ChinaCapital Medical University Affiliated Beijing Children's Hospital, Beijing 100045, ChinaCapital Medical University Affiliated Beijing Children's Hospital, Beijing 100045, ChinaCapital Medical University Affiliated Beijing Children's Hospital, Beijing 100045, China[Objective] To analyze the production of platelet antibodies in children with congenital heart disease, identify the types of antibodies, and explore their effects on platelet count, coagulation function and platelet function. [Methods] A retrospective analysis was conducted on 3 504 congenital heart disease patients without a history of blood transfusion who were treated at Beijing Children's Hospital between January 2019 and June 2024 to study the positive rate of platelet antibodies. Platelet antibody types were detected using the solid-phase agglutination method, and the platelet count and coagulation function of the children were analyzed. The impact of platelet antibodies on platelet function was evaluated using a coagulation and platelet function analyzer. [Results] The positive rate of platelet antibody in children with congenital heart disease with no history of blood transfusion was 9.7% (341/3 504), higher than the overall positive rate of 6.6% (2 657/40 311) in the general pediatric population. The platelet antibodies in congenital heart disease cases with positive platelet antibodies were mainly autoantibodies. There was no significant difference in platelet count between antibody-positive children and antibody-negative children. However, the prothrombin time (s) of antibody-positive children was significantly longer than that of antibody-negative children[(12.19±1.07) vs (11.32±0.77)]. Platelets sensitized by antibodies showed a significant reduction in function compared to non-sensitized platelets. [Conclusion] Children with congenital heart disease have a high rate of positivity for autoantibodies, which are associated with abnormalities in coagulation function and can lead to reduced platelet function.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.12.008&lang=encongenital heart diseaseplatelet antibodiescoagulationplatelet function |
| spellingShingle | ZHEN Zida FU Xiaoyan ZHANG Huimin LIU Yu MA Shuxuan Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function Zhongguo shuxue zazhi congenital heart disease platelet antibodies coagulation platelet function |
| title | Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function |
| title_full | Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function |
| title_fullStr | Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function |
| title_full_unstemmed | Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function |
| title_short | Platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function |
| title_sort | platelet antibody production in children with congenital heart disease leading to coagulation dysfunction and reduced platelet function |
| topic | congenital heart disease platelet antibodies coagulation platelet function |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.12.008&lang=en |
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