Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–2020)
Abstract Background Worldwide, antimicrobial resistance (AMR) has grown to represent a serious threat to the diagnosis, management, and prevention of bacterial diseases. Due to their multidrug resistance attributes, the WHO has classified extended-spectrum-β-lactamase-producing Enterobacteriaceae (E...
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BMC
2025-01-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-024-02267-8 |
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| author | Getahun Kahsay Abay Mebrahtu Teweldemedhin Shfare Teklay Gebrecherkos Teklu Kibriti Mehari Kidane Tsega Kahsay Gebremeskel Atsebaha Gebrekidan Kahsay Kebede Embaye Gezae Saravanan Muthupandian Tsehaye Asmelash Degene |
| author_facet | Getahun Kahsay Abay Mebrahtu Teweldemedhin Shfare Teklay Gebrecherkos Teklu Kibriti Mehari Kidane Tsega Kahsay Gebremeskel Atsebaha Gebrekidan Kahsay Kebede Embaye Gezae Saravanan Muthupandian Tsehaye Asmelash Degene |
| author_sort | Getahun Kahsay Abay |
| collection | DOAJ |
| description | Abstract Background Worldwide, antimicrobial resistance (AMR) has grown to represent a serious threat to the diagnosis, management, and prevention of bacterial diseases. Due to their multidrug resistance attributes, the WHO has classified extended-spectrum-β-lactamase-producing Enterobacteriaceae (ESBL-PE)-associated infections as infections of critical significance, posing a serious risk to human health. Thus, the goal of this systematic review and meta-analysis was to assess the pooled prevalence of ESBL-PE and AMR among strains causing clinical infections in Africa. Methods In this systematic review and meta-analysis, two investigators independently made an electronic search in Google Scholar and PubMed databases using related keywords and corresponding “MeSH.” terms for the PubMed. The accessed studies were screened, assessed for eligibility, and critically evaluated as per the PRISMA guidelines. The prevalence and 95% confidence intervals (CI) for ESBL-PE in Africa were evaluated using a random-effects model of a meta-analysis. As a visual and statistical way assessment, the funnel plot and Egger's test were utilized to assess the risk of bias or publication bias, with a statistically significant level of bias being determined at p < 0.05. Results Twenty-six studies were included in the meta-analysis. Among the included studies done in Africa, the overall pooled proportion of ESBL-PE was reported to be 28% (95% CI 25–31%). ESBL-PE prevalence differed by region, the pooled estimates for East and North Africa were 29% (95% CI 20–38%) and 19% (95% CI 6–33%), respectively. The greatest sub-group analysis of pooled estimates among bacterial isolates was found in Klebsiella. pneumoniae, at 73% (95% CI 62–85%), while Proteus mirabilis had the lowest, at 40% (95% CI 1–81%). Conclusions In Africa, ESBL-PE is noticeably prevalent. The included studies demonstrated a significant variation in ESBL-PE resistance among the countries. This illustrates the necessity of actively monitoring antimicrobial resistance in Africa to develop interventions aimed at halting the spread of ESBL-PE. |
| format | Article |
| id | doaj-art-0b9e6d591b0d4cb4941f7dec0b3ac6a7 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | European Journal of Medical Research |
| spelling | doaj-art-0b9e6d591b0d4cb4941f7dec0b3ac6a72025-01-12T12:12:44ZengBMCEuropean Journal of Medical Research2047-783X2025-01-0130111410.1186/s40001-024-02267-8Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–2020)Getahun Kahsay Abay0Mebrahtu Teweldemedhin Shfare1Teklay Gebrecherkos Teklu2Kibriti Mehari Kidane3Tsega Kahsay Gebremeskel4Atsebaha Gebrekidan Kahsay5Kebede Embaye Gezae6Saravanan Muthupandian7Tsehaye Asmelash Degene8Department of Medical Microbiology & Immunology, College of Health Sciences, Mekelle UniversityDepartment of Medical Microbiology & Immunology, College of Health Sciences, Mekelle UniversityDepartment of Medical Microbiology & Immunology, College of Health Sciences, Mekelle UniversityDepartment of Medical Microbiology & Immunology, College of Health Sciences, Mekelle UniversityDepartment of Medical Microbiology & Immunology, College of Health Sciences, Mekelle UniversityDepartment of Medical Microbiology & Immunology, College of Health Sciences, Mekelle UniversityDepartment of Biostatistics, School of Public Health, College of Health Sciences, Mekelle UniversityDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of TabukDepartment of Medical Microbiology & Immunology, College of Health Sciences, Mekelle UniversityAbstract Background Worldwide, antimicrobial resistance (AMR) has grown to represent a serious threat to the diagnosis, management, and prevention of bacterial diseases. Due to their multidrug resistance attributes, the WHO has classified extended-spectrum-β-lactamase-producing Enterobacteriaceae (ESBL-PE)-associated infections as infections of critical significance, posing a serious risk to human health. Thus, the goal of this systematic review and meta-analysis was to assess the pooled prevalence of ESBL-PE and AMR among strains causing clinical infections in Africa. Methods In this systematic review and meta-analysis, two investigators independently made an electronic search in Google Scholar and PubMed databases using related keywords and corresponding “MeSH.” terms for the PubMed. The accessed studies were screened, assessed for eligibility, and critically evaluated as per the PRISMA guidelines. The prevalence and 95% confidence intervals (CI) for ESBL-PE in Africa were evaluated using a random-effects model of a meta-analysis. As a visual and statistical way assessment, the funnel plot and Egger's test were utilized to assess the risk of bias or publication bias, with a statistically significant level of bias being determined at p < 0.05. Results Twenty-six studies were included in the meta-analysis. Among the included studies done in Africa, the overall pooled proportion of ESBL-PE was reported to be 28% (95% CI 25–31%). ESBL-PE prevalence differed by region, the pooled estimates for East and North Africa were 29% (95% CI 20–38%) and 19% (95% CI 6–33%), respectively. The greatest sub-group analysis of pooled estimates among bacterial isolates was found in Klebsiella. pneumoniae, at 73% (95% CI 62–85%), while Proteus mirabilis had the lowest, at 40% (95% CI 1–81%). Conclusions In Africa, ESBL-PE is noticeably prevalent. The included studies demonstrated a significant variation in ESBL-PE resistance among the countries. This illustrates the necessity of actively monitoring antimicrobial resistance in Africa to develop interventions aimed at halting the spread of ESBL-PE.https://doi.org/10.1186/s40001-024-02267-8Antimicrobial resistanceExtended-spectrum ß-lactamaseEnterobacteriaceaeAfrica |
| spellingShingle | Getahun Kahsay Abay Mebrahtu Teweldemedhin Shfare Teklay Gebrecherkos Teklu Kibriti Mehari Kidane Tsega Kahsay Gebremeskel Atsebaha Gebrekidan Kahsay Kebede Embaye Gezae Saravanan Muthupandian Tsehaye Asmelash Degene Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–2020) European Journal of Medical Research Antimicrobial resistance Extended-spectrum ß-lactamase Enterobacteriaceae Africa |
| title | Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–2020) |
| title_full | Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–2020) |
| title_fullStr | Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–2020) |
| title_full_unstemmed | Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–2020) |
| title_short | Extended-spectrum β-lactamase production and antimicrobial resistance among Enterobacteriaceae causing clinical infections in Africa: a systematic review and meta-analysis (2012–2020) |
| title_sort | extended spectrum β lactamase production and antimicrobial resistance among enterobacteriaceae causing clinical infections in africa a systematic review and meta analysis 2012 2020 |
| topic | Antimicrobial resistance Extended-spectrum ß-lactamase Enterobacteriaceae Africa |
| url | https://doi.org/10.1186/s40001-024-02267-8 |
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