Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology
The main focus of cardio-oncology has been the prevention and treatment of the cardiac toxicity of chemotherapy and radiotherapy. Furthermore, several targeted therapies have been associated with unexpected cardiotoxic side-effects. Recently, epidemiological studies reported a higher incidence of ca...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2019-05-01
|
| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articles/Bidirectional-Relationship-Cancer-Heart-Failure-Cardio-Oncology |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846122514410897408 |
|---|---|
| author | Edoardo Bertero Pietro Ameri Christoph Maack |
| author_facet | Edoardo Bertero Pietro Ameri Christoph Maack |
| author_sort | Edoardo Bertero |
| collection | DOAJ |
| description | The main focus of cardio-oncology has been the prevention and treatment of the cardiac toxicity of chemotherapy and radiotherapy. Furthermore, several targeted therapies have been associated with unexpected cardiotoxic side-effects. Recently, epidemiological studies reported a higher incidence of cancer in patients with heart failure (HF) compared with individuals without HF. On this basis, it has been proposed that HF might represent an oncogenic condition. This hypothesis is supported by preclinical studies demonstrating that hyperactivation of the sympathetic nervous system and renin–angiotensin–aldosterone system, which is a hallmark of HF, promotes cancer growth and dissemination. Another intriguing possibility is that the co-occurrence of HF and cancer is promoted by a common pathological milieu characterised by a state of chronic low-grade inflammation, which predisposes to both diseases. In this review, we provide an overview of the mechanisms underlying the bidirectional relationship between HF and cancer. |
| format | Article |
| id | doaj-art-0b819998f65a4295a9b2b3e0d47764d9 |
| institution | Kabale University |
| issn | 2057-7540 2057-7559 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj-art-0b819998f65a4295a9b2b3e0d47764d92024-12-14T16:01:22ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592019-05-015210611110.15420/cfr.2019.1.2Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncologyEdoardo Bertero0Pietro Ameri1Christoph Maack2Comprehensive Heart Failure Center, University Clinic Würzburg, Würzburg, GermanyCardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino – IRCCS Italian Cardiovascular Network, Genova, Italy; Department of Internal Medicine and Centre of Excellence for Biomedical Research, University of Genova, Genova, ItalyComprehensive Heart Failure Center, University Clinic Würzburg, Würzburg, GermanyThe main focus of cardio-oncology has been the prevention and treatment of the cardiac toxicity of chemotherapy and radiotherapy. Furthermore, several targeted therapies have been associated with unexpected cardiotoxic side-effects. Recently, epidemiological studies reported a higher incidence of cancer in patients with heart failure (HF) compared with individuals without HF. On this basis, it has been proposed that HF might represent an oncogenic condition. This hypothesis is supported by preclinical studies demonstrating that hyperactivation of the sympathetic nervous system and renin–angiotensin–aldosterone system, which is a hallmark of HF, promotes cancer growth and dissemination. Another intriguing possibility is that the co-occurrence of HF and cancer is promoted by a common pathological milieu characterised by a state of chronic low-grade inflammation, which predisposes to both diseases. In this review, we provide an overview of the mechanisms underlying the bidirectional relationship between HF and cancer.https://www.cfrjournal.com/articles/Bidirectional-Relationship-Cancer-Heart-Failure-Cardio-Oncology |
| spellingShingle | Edoardo Bertero Pietro Ameri Christoph Maack Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology Cardiac Failure Review |
| title | Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology |
| title_full | Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology |
| title_fullStr | Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology |
| title_full_unstemmed | Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology |
| title_short | Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology |
| title_sort | bidirectional relationship between cancer and heart failure old and new issues in cardio oncology |
| url | https://www.cfrjournal.com/articles/Bidirectional-Relationship-Cancer-Heart-Failure-Cardio-Oncology |
| work_keys_str_mv | AT edoardobertero bidirectionalrelationshipbetweencancerandheartfailureoldandnewissuesincardiooncology AT pietroameri bidirectionalrelationshipbetweencancerandheartfailureoldandnewissuesincardiooncology AT christophmaack bidirectionalrelationshipbetweencancerandheartfailureoldandnewissuesincardiooncology |