Increasing the biomolecular relevance of cell culture practice
Abstract The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. The biomolecular composition of commonly used supplements differs from that of a physiological environment, affecting the validity of conclusions drawn from in vitro studies. This article di...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-024-01095-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559115844812800 |
|---|---|
| author | Raluca E. Ghebosu Lawrence Hui Joy Wolfram |
| author_facet | Raluca E. Ghebosu Lawrence Hui Joy Wolfram |
| author_sort | Raluca E. Ghebosu |
| collection | DOAJ |
| description | Abstract The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. The biomolecular composition of commonly used supplements differs from that of a physiological environment, affecting the validity of conclusions drawn from in vitro studies. This article discusses the advantages and disadvantages of common supplements, including context-dependent considerations for supplement selection to improve biomolecular relevance, especially in nanomedicine and extracellular vesicle research. |
| format | Article |
| id | doaj-art-0b24f650a0e74e44aee28a2b76182df0 |
| institution | Kabale University |
| issn | 1423-0127 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj-art-0b24f650a0e74e44aee28a2b76182df02025-01-05T12:42:30ZengBMCJournal of Biomedical Science1423-01272025-01-0132111010.1186/s12929-024-01095-6Increasing the biomolecular relevance of cell culture practiceRaluca E. Ghebosu0Lawrence Hui1Joy Wolfram2Australian Institute for Bioengineering and Nanotechnology, The University of QueenslandAustralian Institute for Bioengineering and Nanotechnology, The University of QueenslandAustralian Institute for Bioengineering and Nanotechnology, The University of QueenslandAbstract The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. The biomolecular composition of commonly used supplements differs from that of a physiological environment, affecting the validity of conclusions drawn from in vitro studies. This article discusses the advantages and disadvantages of common supplements, including context-dependent considerations for supplement selection to improve biomolecular relevance, especially in nanomedicine and extracellular vesicle research.https://doi.org/10.1186/s12929-024-01095-6Chemically defined mediumFetal bovine serum (FBS)PlasmaSerumSupplement |
| spellingShingle | Raluca E. Ghebosu Lawrence Hui Joy Wolfram Increasing the biomolecular relevance of cell culture practice Journal of Biomedical Science Chemically defined medium Fetal bovine serum (FBS) Plasma Serum Supplement |
| title | Increasing the biomolecular relevance of cell culture practice |
| title_full | Increasing the biomolecular relevance of cell culture practice |
| title_fullStr | Increasing the biomolecular relevance of cell culture practice |
| title_full_unstemmed | Increasing the biomolecular relevance of cell culture practice |
| title_short | Increasing the biomolecular relevance of cell culture practice |
| title_sort | increasing the biomolecular relevance of cell culture practice |
| topic | Chemically defined medium Fetal bovine serum (FBS) Plasma Serum Supplement |
| url | https://doi.org/10.1186/s12929-024-01095-6 |
| work_keys_str_mv | AT ralucaeghebosu increasingthebiomolecularrelevanceofcellculturepractice AT lawrencehui increasingthebiomolecularrelevanceofcellculturepractice AT joywolfram increasingthebiomolecularrelevanceofcellculturepractice |