GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY
ABSTRACT Objective: To document the effects of genicular nerve ablation in patients with severe knee osteoarthritis (OAJ) at 1 and 3 months. Methods: Prospective, randomized, and controlled trial with 35 patients with grade IV knee osteoarthritis according to Kelgren & Lawrence, undergoing gen...
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Sociedade Brasileira de Ortopedia e Traumatologia
2025-08-01
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| Series: | Acta Ortopédica Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522025000308800&lng=en&tlng=en |
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| author | João Vital Arthur Maradona Oliveira Dias Vitor Ricardo Alves Pereira de Moraes Matheus Trindade Bruxelas de Freitas Matheus Manolo Arouca Guilherme Pereira Ocampos Olavo Pires de Camargo Márcia Uchoa de Rezende |
| author_facet | João Vital Arthur Maradona Oliveira Dias Vitor Ricardo Alves Pereira de Moraes Matheus Trindade Bruxelas de Freitas Matheus Manolo Arouca Guilherme Pereira Ocampos Olavo Pires de Camargo Márcia Uchoa de Rezende |
| author_sort | João Vital Arthur Maradona Oliveira Dias |
| collection | DOAJ |
| description | ABSTRACT Objective: To document the effects of genicular nerve ablation in patients with severe knee osteoarthritis (OAJ) at 1 and 3 months. Methods: Prospective, randomized, and controlled trial with 35 patients with grade IV knee osteoarthritis according to Kelgren & Lawrence, undergoing genicular nerve ablation with pulsed radiofrequency (PRF) or phenol. Outcomes were assessed at baseline, 1 month, and 3 months using the Numeric Rating Scale (NRS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), the 30-Second Chair Stand Test (TSL30), and the Timed Up and Go (TUG) test. Results: The groups were similar at baseline. Both groups improved similarly up to 3 months (p<0.001). NRS decreased by an average of 30% from baseline to all subsequent assessments (p<0.05). TUG decreased between baseline and one month post-procedure (p=0.001), while TSL30 increased from baseline to one and three months (p<0.05). The average behavior of patients was equal between groups over the evaluations for all scores (p Interaction > 0.05). None of the scores differed between groups, regardless of the evaluation period (p Group > 0.05). Conclusions: Genicular nerve ablation in patients with severe OAJ can provide lasting improvements in pain, function, and quality of life. Both methods, phenol and radiofrequency, are effective. Level of Evidence I; Controlled Randomized Clinical Trial. |
| format | Article |
| id | doaj-art-0b0d49ec6f2b46b4812b31397c7544e1 |
| institution | Kabale University |
| issn | 1413-7852 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Acta Ortopédica Brasileira |
| spelling | doaj-art-0b0d49ec6f2b46b4812b31397c7544e12025-08-20T03:47:16ZengSociedade Brasileira de Ortopedia e TraumatologiaActa Ortopédica Brasileira1413-78522025-08-0133310.1590/1413-785220253303e289218GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDYJoão Vital Arthur Maradona Oliveira Diashttps://orcid.org/0009-0004-9267-6987Vitor Ricardo Alves Pereira de Moraeshttps://orcid.org/0009-0003-7040-780XMatheus Trindade Bruxelas de Freitashttps://orcid.org/0009-0001-2535-3529Matheus Manolo Aroucahttps://orcid.org/0000-0002-0994-9680Guilherme Pereira Ocamposhttps://orcid.org/0000-0003-0052-6769Olavo Pires de Camargohttps://orcid.org/0000-0002-1128-7292Márcia Uchoa de Rezendehttps://orcid.org/0000-0002-2020-9501ABSTRACT Objective: To document the effects of genicular nerve ablation in patients with severe knee osteoarthritis (OAJ) at 1 and 3 months. Methods: Prospective, randomized, and controlled trial with 35 patients with grade IV knee osteoarthritis according to Kelgren & Lawrence, undergoing genicular nerve ablation with pulsed radiofrequency (PRF) or phenol. Outcomes were assessed at baseline, 1 month, and 3 months using the Numeric Rating Scale (NRS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), the 30-Second Chair Stand Test (TSL30), and the Timed Up and Go (TUG) test. Results: The groups were similar at baseline. Both groups improved similarly up to 3 months (p<0.001). NRS decreased by an average of 30% from baseline to all subsequent assessments (p<0.05). TUG decreased between baseline and one month post-procedure (p=0.001), while TSL30 increased from baseline to one and three months (p<0.05). The average behavior of patients was equal between groups over the evaluations for all scores (p Interaction > 0.05). None of the scores differed between groups, regardless of the evaluation period (p Group > 0.05). Conclusions: Genicular nerve ablation in patients with severe OAJ can provide lasting improvements in pain, function, and quality of life. Both methods, phenol and radiofrequency, are effective. Level of Evidence I; Controlled Randomized Clinical Trial.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522025000308800&lng=en&tlng=enOsteoarthritis, KneePainPhenolRadiofrequency Ablation |
| spellingShingle | João Vital Arthur Maradona Oliveira Dias Vitor Ricardo Alves Pereira de Moraes Matheus Trindade Bruxelas de Freitas Matheus Manolo Arouca Guilherme Pereira Ocampos Olavo Pires de Camargo Márcia Uchoa de Rezende GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY Acta Ortopédica Brasileira Osteoarthritis, Knee Pain Phenol Radiofrequency Ablation |
| title | GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY |
| title_full | GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY |
| title_fullStr | GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY |
| title_full_unstemmed | GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY |
| title_short | GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY |
| title_sort | genicular nerve ablation in knee osteoarthritis a randomized prospective study |
| topic | Osteoarthritis, Knee Pain Phenol Radiofrequency Ablation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522025000308800&lng=en&tlng=en |
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