Effect of changes in skin properties due to diabetes mellitus on the titration period of transdermal fentanyl: single-center retrospective study and diabetic animal model study

Effect of changes in skin properties due to diabetes mellitus on the titration period of transdermal fentanyl: single-center retrospective study and diabetic animal model study

Abstract Background In the dose titration of transdermal fentanyl to prevent unrelieved pain, it is important to consider not only dose adjustment, but also the titration period, which is influenced by the time required to reach the steady state. Many patients with cancer pain experience comorbiditi...

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Main Authors: Satoshi Mizuno, Makiko Takabayashi, Hiroko Makihara, Kazuhiro Ogai, Kei Tsukui, Yuriko Ito, Takahiro Kawakami, Yusuke Hara, Arimi Fujita, Yoshihiro Tokudome, Tomoko Akase, Yukio Kato, Tsutomu Shimada, Yoshimichi Sai
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Transdermal fentanyl
Opioid titration
GK rats
Diabetes mellitus
Stratum corneum
Intercellular lipids
Online Access:https://doi.org/10.1186/s40780-024-00402-5
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https://doi.org/10.1186/s40780-024-00402-5

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