Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy
Adverse drug reactions are a serious problem for health and one of the main reasons for treatment failure with antiepileptic drugs. In this study, we determined the HLA-DQB1 and -DPB1 alleles in the blood samples of 44 epileptic patients receiving carbamazepine treatment, including 21 patients with...
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Vietnam Ministry of Science and Technology
2024-12-01
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| Series: | Vietnam Journal of Science, Technology and Engineering |
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| Online Access: | https://vietnamscience.vjst.vn/index.php/vjste/article/view/1244 |
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| author | Thi Thanh Nhan Le Thi Tu Linh Nguyen Lan Phuong Le Doan Thuy Nguyen Van Lieu Nguyen Thi Van Anh Nguyen Hong Thai Trinh |
| author_facet | Thi Thanh Nhan Le Thi Tu Linh Nguyen Lan Phuong Le Doan Thuy Nguyen Van Lieu Nguyen Thi Van Anh Nguyen Hong Thai Trinh |
| author_sort | Thi Thanh Nhan Le |
| collection | DOAJ |
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Adverse drug reactions are a serious problem for health and one of the main reasons for treatment failure with antiepileptic drugs. In this study, we determined the HLA-DQB1 and -DPB1 alleles in the blood samples of 44 epileptic patients receiving carbamazepine treatment, including 21 patients with hypersensitivity and 23 patients with tolerance, using the next-generation sequencing method. We identified 19 HLA-DQB1 alleles, of which 13 were in the hypersensitive group and 15 were in the tolerant group. The frequency of the HLA-DQB1*03:01:01 allele was highest in both groups. Although the frequency of the HLA-DQB1*03:03:02 allele in the hypersensitive group was higher than that in the tolerant group (p=0.0431), this difference was not statistically significant after applying the Bonferroni correction (pc=0.5249). However, the evidence of in silico interaction between CBZ and HLA- DQB1*03:03 at the peptide-binding cleft was suggested. For HLA-DPB1, 16 alleles were found in epileptic patients, with the HLA-DPB1*05:01:01 allele having the highest frequency; however, no allele was associated with the risk of hypersensitivity to carbamazepine in epileptic patients. Our study demonstrates that the HLA-DQB1*03:03:02 allele tended to behave as a susceptibility factor for carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy.
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| format | Article |
| id | doaj-art-0b081c41b34b4116a96d1cd3b47ef9c0 |
| institution | Kabale University |
| issn | 2525-2461 2615-9937 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Vietnam Ministry of Science and Technology |
| record_format | Article |
| series | Vietnam Journal of Science, Technology and Engineering |
| spelling | doaj-art-0b081c41b34b4116a96d1cd3b47ef9c02025-01-06T02:53:53ZengVietnam Ministry of Science and TechnologyVietnam Journal of Science, Technology and Engineering2525-24612615-99372024-12-0166410.31276/VJSTE.2023.0041Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsyThi Thanh Nhan LeThi Tu Linh NguyenLan Phuong LeDoan Thuy NguyenVan Lieu NguyenThi Van Anh NguyenHong Thai Trinh Adverse drug reactions are a serious problem for health and one of the main reasons for treatment failure with antiepileptic drugs. In this study, we determined the HLA-DQB1 and -DPB1 alleles in the blood samples of 44 epileptic patients receiving carbamazepine treatment, including 21 patients with hypersensitivity and 23 patients with tolerance, using the next-generation sequencing method. We identified 19 HLA-DQB1 alleles, of which 13 were in the hypersensitive group and 15 were in the tolerant group. The frequency of the HLA-DQB1*03:01:01 allele was highest in both groups. Although the frequency of the HLA-DQB1*03:03:02 allele in the hypersensitive group was higher than that in the tolerant group (p=0.0431), this difference was not statistically significant after applying the Bonferroni correction (pc=0.5249). However, the evidence of in silico interaction between CBZ and HLA- DQB1*03:03 at the peptide-binding cleft was suggested. For HLA-DPB1, 16 alleles were found in epileptic patients, with the HLA-DPB1*05:01:01 allele having the highest frequency; however, no allele was associated with the risk of hypersensitivity to carbamazepine in epileptic patients. Our study demonstrates that the HLA-DQB1*03:03:02 allele tended to behave as a susceptibility factor for carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy. https://vietnamscience.vjst.vn/index.php/vjste/article/view/1244carbamazepineepilepsyHLA-DPB1HLA-DQB1*03:03:02 |
| spellingShingle | Thi Thanh Nhan Le Thi Tu Linh Nguyen Lan Phuong Le Doan Thuy Nguyen Van Lieu Nguyen Thi Van Anh Nguyen Hong Thai Trinh Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy Vietnam Journal of Science, Technology and Engineering carbamazepine epilepsy HLA-DPB1 HLA-DQB1*03:03:02 |
| title | Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy |
| title_full | Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy |
| title_fullStr | Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy |
| title_full_unstemmed | Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy |
| title_short | Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy |
| title_sort | association between hla dqb1 dpb1 alleles and risk of carbamazepine induced hypersensitivity reactions in vietnamese patients with epilepsy |
| topic | carbamazepine epilepsy HLA-DPB1 HLA-DQB1*03:03:02 |
| url | https://vietnamscience.vjst.vn/index.php/vjste/article/view/1244 |
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