Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer
Breast cancer is among the most common neoplasms in women worldwide, and timely detection is important to ensure the greatest chance of survival. Metal-organic frameworks (MOFs) possess specific advantages for application in biosensors because they possess a high specific surface area, tunable pore...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Sensing and Bio-Sensing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180425001217 |
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| author | Xiaoxia Yao Wei Chen Chi Zhang Weixuan Shao Mohammadreza Shokouhimehr Can Guo Zhengchun Liu |
| author_facet | Xiaoxia Yao Wei Chen Chi Zhang Weixuan Shao Mohammadreza Shokouhimehr Can Guo Zhengchun Liu |
| author_sort | Xiaoxia Yao |
| collection | DOAJ |
| description | Breast cancer is among the most common neoplasms in women worldwide, and timely detection is important to ensure the greatest chance of survival. Metal-organic frameworks (MOFs) possess specific advantages for application in biosensors because they possess a high specific surface area, tunable pore structure, and excellent biocompatibility. This paper summarizes the research progress of MOF-based aptamer sensors for the early detection of biomarkers of breast cancer, including progress in single-biomarker and multiplex sensing and the use of various detection methods in aptamer-based sensors. Furthermore, it discusses novel component design, optimization of detection methods, and the expansion of clinical applications with MOF-based aptamer sensors. Functionalization and adjustment of MOFs through the introduction of new aptamers and techniques have improved sensor efficiency and provided new paths for early cancer diagnosis. Despite advancements, sensitivity, selectivity, and clinical feasibility concerns are areas that require more efforts. |
| format | Article |
| id | doaj-art-0aaf98e61b334df9bad9d422e794758d |
| institution | Kabale University |
| issn | 2214-1804 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj-art-0aaf98e61b334df9bad9d422e794758d2025-08-20T03:58:49ZengElsevierSensing and Bio-Sensing Research2214-18042025-08-014910085510.1016/j.sbsr.2025.100855Metal-organic framework-based aptamer sensors for early diagnosis of breast cancerXiaoxia Yao0Wei Chen1Chi Zhang2Weixuan Shao3Mohammadreza Shokouhimehr4Can Guo5Zhengchun Liu6School of Basic Medicine, Xinjiang Medical University, Urumqi 830017, China; XiangYa School of Basic Medical Sciences, Central South University, Changsha 410008, China; School of Electronics Information, Central South University, Changsha 410083, ChinaDepartment of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha 410008, ChinaSchool of Electronics Information, Central South University, Changsha 410083, ChinaSchool of Electronics Information, Central South University, Changsha 410083, ChinaDepartment of Materials Science and Engineering, Research Institute of Advanced Materials, Seoul National University, Seoul 08826, Republic of Korea; Institute of Nanosensor Technology, Hanyang University, Ansan 15588, Republic of KoreaXiangYa School of Basic Medical Sciences, Central South University, Changsha 410008, China; Corresponding authors.School of Electronics Information, Central South University, Changsha 410083, China; Corresponding authors.Breast cancer is among the most common neoplasms in women worldwide, and timely detection is important to ensure the greatest chance of survival. Metal-organic frameworks (MOFs) possess specific advantages for application in biosensors because they possess a high specific surface area, tunable pore structure, and excellent biocompatibility. This paper summarizes the research progress of MOF-based aptamer sensors for the early detection of biomarkers of breast cancer, including progress in single-biomarker and multiplex sensing and the use of various detection methods in aptamer-based sensors. Furthermore, it discusses novel component design, optimization of detection methods, and the expansion of clinical applications with MOF-based aptamer sensors. Functionalization and adjustment of MOFs through the introduction of new aptamers and techniques have improved sensor efficiency and provided new paths for early cancer diagnosis. Despite advancements, sensitivity, selectivity, and clinical feasibility concerns are areas that require more efforts.http://www.sciencedirect.com/science/article/pii/S2214180425001217Metal-organic frameworkAptamerBreast cancer biomarkerBiosensorEarly diagnosis |
| spellingShingle | Xiaoxia Yao Wei Chen Chi Zhang Weixuan Shao Mohammadreza Shokouhimehr Can Guo Zhengchun Liu Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer Sensing and Bio-Sensing Research Metal-organic framework Aptamer Breast cancer biomarker Biosensor Early diagnosis |
| title | Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer |
| title_full | Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer |
| title_fullStr | Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer |
| title_full_unstemmed | Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer |
| title_short | Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer |
| title_sort | metal organic framework based aptamer sensors for early diagnosis of breast cancer |
| topic | Metal-organic framework Aptamer Breast cancer biomarker Biosensor Early diagnosis |
| url | http://www.sciencedirect.com/science/article/pii/S2214180425001217 |
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