Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
Purpose The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical and functional domains longitudinally in young people presenting for mental health care and treatment. Longitudinal tracking of this cohort will allow investigation of the relationships between multiple outcome domain...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/3/e030985.full |
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| author | Daniel F Hermens Sharon L Naismith Adam J Guastella Jan Scott Elizabeth M Scott Ian B Hickie Joanne S Carpenter Frank Iorfino Django White Shane Cross Alissa Nichles Natalia Zmicerevska Jacob J Crouse Jake R Palmer Alexis E Whitton |
| author_facet | Daniel F Hermens Sharon L Naismith Adam J Guastella Jan Scott Elizabeth M Scott Ian B Hickie Joanne S Carpenter Frank Iorfino Django White Shane Cross Alissa Nichles Natalia Zmicerevska Jacob J Crouse Jake R Palmer Alexis E Whitton |
| author_sort | Daniel F Hermens |
| collection | DOAJ |
| description | Purpose The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical and functional domains longitudinally in young people presenting for mental health care and treatment. Longitudinal tracking of this cohort will allow investigation of the relationships between multiple outcome domains across the course of care. Subsets of Optymise have completed detailed neuropsychological and neurobiological assessments, permitting investigation of associations between these measures and longitudinal course.Participants Young people (aged 12–30) presenting to clinics coordinated by the BMC were recruited to a research register (n=6743) progressively between June 2008 and July 2018. To date, 2767 individuals have been included in Optymise based on the availability of at least one detailed clinical assessment.Measures Trained researchers use a clinical research proforma to extract key data from clinical files to detail social and occupational functioning, clinical presentation, self-harm and suicidal thoughts and behaviours, alcohol and other substance use, physical health comorbidities, personal and family history of mental illness, and treatment utilisation at the following time points: baseline, 3, 6, 12, 24, 36, 48, and 60 months, and time last seen.Findings to date There is moderate to substantial agreement between raters for data collected via the proforma. While wide variations in individual illness course are clear, social and occupational outcomes suggest that the majority of cohort members show no improvement in functioning over time. Differential rates of longitudinal transition are reported between early and late stages of illness, with a number of baseline factors associated with these transitions. Furthermore, there are longitudinal associations between prior suicide attempts and inferior clinical and functional outcomes.Future plans Future reports will detail the longitudinal course of each outcome domain and examine multidirectional relationships between these domains both cross-sectionally and longitudinally, and explore in subsets the associations between detailed neurobiological measures and clinical, social and functional outcomes. |
| format | Article |
| id | doaj-art-0aa4fe73a95147ef99e082e04ae7e576 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-0aa4fe73a95147ef99e082e04ae7e5762024-12-07T03:10:09ZengBMJ Publishing GroupBMJ Open2044-60552020-03-0110310.1136/bmjopen-2019-030985Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcareDaniel F Hermens0Sharon L Naismith1Adam J Guastella2Jan Scott3Elizabeth M Scott4Ian B Hickie5Joanne S Carpenter6Frank Iorfino7Django White8Shane Cross9Alissa Nichles10Natalia Zmicerevska11Jacob J Crouse12Jake R Palmer13Alexis E Whitton14Thompson Institute, University of the Sunshine Coast, Maroochydore DC, Queensland, AustraliaBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaBrain & Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaNewcastle University, Newcastle upon Tyne, UKBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia1 The University of Sydney Brain and Mind Centre, Camperdown, New South Wales, AustraliaBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaBrain & Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaBrain & Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia1 The University of Sydney Brain and Mind Centre, Camperdown, New South Wales, AustraliaBrain & Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaBrain & Mind Centre, The University of Sydney, Camperdown, New South Wales, AustraliaPurpose The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical and functional domains longitudinally in young people presenting for mental health care and treatment. Longitudinal tracking of this cohort will allow investigation of the relationships between multiple outcome domains across the course of care. Subsets of Optymise have completed detailed neuropsychological and neurobiological assessments, permitting investigation of associations between these measures and longitudinal course.Participants Young people (aged 12–30) presenting to clinics coordinated by the BMC were recruited to a research register (n=6743) progressively between June 2008 and July 2018. To date, 2767 individuals have been included in Optymise based on the availability of at least one detailed clinical assessment.Measures Trained researchers use a clinical research proforma to extract key data from clinical files to detail social and occupational functioning, clinical presentation, self-harm and suicidal thoughts and behaviours, alcohol and other substance use, physical health comorbidities, personal and family history of mental illness, and treatment utilisation at the following time points: baseline, 3, 6, 12, 24, 36, 48, and 60 months, and time last seen.Findings to date There is moderate to substantial agreement between raters for data collected via the proforma. While wide variations in individual illness course are clear, social and occupational outcomes suggest that the majority of cohort members show no improvement in functioning over time. Differential rates of longitudinal transition are reported between early and late stages of illness, with a number of baseline factors associated with these transitions. Furthermore, there are longitudinal associations between prior suicide attempts and inferior clinical and functional outcomes.Future plans Future reports will detail the longitudinal course of each outcome domain and examine multidirectional relationships between these domains both cross-sectionally and longitudinally, and explore in subsets the associations between detailed neurobiological measures and clinical, social and functional outcomes.https://bmjopen.bmj.com/content/10/3/e030985.full |
| spellingShingle | Daniel F Hermens Sharon L Naismith Adam J Guastella Jan Scott Elizabeth M Scott Ian B Hickie Joanne S Carpenter Frank Iorfino Django White Shane Cross Alissa Nichles Natalia Zmicerevska Jacob J Crouse Jake R Palmer Alexis E Whitton Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare BMJ Open |
| title | Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare |
| title_full | Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare |
| title_fullStr | Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare |
| title_full_unstemmed | Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare |
| title_short | Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare |
| title_sort | cohort profile the brain and mind centre optymise cohort tracking multidimensional outcomes in young people presenting for mental healthcare |
| url | https://bmjopen.bmj.com/content/10/3/e030985.full |
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