Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment
Sickle Cell Anaemia (SCA) is the most common inherited blood disorder and is associated with severe morbidity and decreased survival. Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) is the only curative approach. Nevertheless the decision to perform a marrow transplant includes the risk o...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2015-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2060 |
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| author | Katia Paciaroni Gioia De Angelis Cristiano Gallucci Cecilia Alfieri Michela Ribersani Andrea Roveda Antonella Isgrò Marco Marziali Ivan Pietro Aloi Alessandro Inserra Javid Gaziev Pietro Sodani Guido Lucarelli |
| author_facet | Katia Paciaroni Gioia De Angelis Cristiano Gallucci Cecilia Alfieri Michela Ribersani Andrea Roveda Antonella Isgrò Marco Marziali Ivan Pietro Aloi Alessandro Inserra Javid Gaziev Pietro Sodani Guido Lucarelli |
| author_sort | Katia Paciaroni |
| collection | DOAJ |
| description | Sickle Cell Anaemia (SCA) is the most common inherited blood disorder and is associated with severe morbidity and decreased survival. Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) is the only curative approach. Nevertheless the decision to perform a marrow transplant includes the risk of major complications and mortality transplant related. The infections represent the main cause of mortality for SCA patients undergoing transplant. Invasive Pulmonary Aspergillosis (IPA) is a devastating opportunistic infection and remains a significant cause of morbidity and mortality in HSCT recipients. Data regarding IPA in the setting of SCA are lacking. In the present report, we describe a patient with SCA who developed IPA after allogeneic bone marrow transplant. The fungal infection was treated by systemic antifungal therapy in addition to the surgery, despite mild chronic GVHD and with continuing immunosuppression therapy. This case shows that IPA occurring in bone marrow recipient with SCA can be successful treated |
| format | Article |
| id | doaj-art-0a726cdebb4d4721b7ae2ce4b32b0f63 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2015-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-0a726cdebb4d4721b7ae2ce4b32b0f632024-12-02T09:47:38ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062015-08-0171e2015006e201500610.4084/mjhid.2015.0061516Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful TreatmentKatia Paciaroni0Gioia De Angelis1Cristiano Gallucci2Cecilia AlfieriMichela Ribersani3Andrea Roveda4Antonella Isgrò5Marco Marziali6Ivan Pietro Aloi7Alessandro Inserra8Javid Gaziev9Pietro Sodani10Guido Lucarelli11International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyDepartments of Surgery, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, ItalyDepartments of Surgery, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalyInternational Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, ItalySickle Cell Anaemia (SCA) is the most common inherited blood disorder and is associated with severe morbidity and decreased survival. Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) is the only curative approach. Nevertheless the decision to perform a marrow transplant includes the risk of major complications and mortality transplant related. The infections represent the main cause of mortality for SCA patients undergoing transplant. Invasive Pulmonary Aspergillosis (IPA) is a devastating opportunistic infection and remains a significant cause of morbidity and mortality in HSCT recipients. Data regarding IPA in the setting of SCA are lacking. In the present report, we describe a patient with SCA who developed IPA after allogeneic bone marrow transplant. The fungal infection was treated by systemic antifungal therapy in addition to the surgery, despite mild chronic GVHD and with continuing immunosuppression therapy. This case shows that IPA occurring in bone marrow recipient with SCA can be successful treatedhttp://www.mjhid.org/index.php/mjhid/article/view/2060Sickle Cell Anaemia- Aspergillus Infection-Bone Marrow Transplant |
| spellingShingle | Katia Paciaroni Gioia De Angelis Cristiano Gallucci Cecilia Alfieri Michela Ribersani Andrea Roveda Antonella Isgrò Marco Marziali Ivan Pietro Aloi Alessandro Inserra Javid Gaziev Pietro Sodani Guido Lucarelli Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment Mediterranean Journal of Hematology and Infectious Diseases Sickle Cell Anaemia- Aspergillus Infection-Bone Marrow Transplant |
| title | Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment |
| title_full | Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment |
| title_fullStr | Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment |
| title_full_unstemmed | Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment |
| title_short | Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment |
| title_sort | invasive pulmonary aspergillosis in a sickle cell patient transplant recipient a successful treatment |
| topic | Sickle Cell Anaemia- Aspergillus Infection-Bone Marrow Transplant |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2060 |
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