Genome-wide DNA methylation profiles of colorectal tumors in Lynch syndrome and familial adenomatous polyposis

Genome-wide DNA methylation profiles of colorectal tumors in Lynch syndrome and familial adenomatous polyposis

Abstract Background Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are hereditary cancer predisposing syndromes characterized by increased risk of especially early-onset colorectal cancer. Predisposition to LS is caused by germline mutations in DNA mismatch repair genes leading to elev...

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Main Authors: Satu Mäki-Nevala, Anni Kauppinen, Alisa Olkinuora, Aleksi Laiho, Petri Törönen, Laura Renkonen-Sinisalo, Anna Lepistö, Toni T. Seppälä, Jukka-Pekka Mecklin, Päivi Peltomäki
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Clinical Epigenetics
Subjects:
Lynch syndrome
Familial adenomatous polyposis
Colorectal cancer
Colon adenoma
DNA methylation
Tumorigenesis
Online Access:https://doi.org/10.1186/s13148-025-01940-x
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