Current status and new directions for hepatocellular carcinoma diagnosis
Liver cancer ranks as the sixth most common cancer globally, with hepatocellular carcinoma (HCC) accounting for approximately 75%–85% of cases. Most patients present with moderately advanced disease, while those with advanced HCC face limited and ineffective treatment options. Despite diagnostic eff...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Liver Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542568424000680 |
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| author | Jinqi Tu Bo Wang Xiaoming Wang Kugeng Huo Wanting Hu Rongli Zhang Jinyao Li Shijie Zhu Qionglin Liang Shuxin Han |
| author_facet | Jinqi Tu Bo Wang Xiaoming Wang Kugeng Huo Wanting Hu Rongli Zhang Jinyao Li Shijie Zhu Qionglin Liang Shuxin Han |
| author_sort | Jinqi Tu |
| collection | DOAJ |
| description | Liver cancer ranks as the sixth most common cancer globally, with hepatocellular carcinoma (HCC) accounting for approximately 75%–85% of cases. Most patients present with moderately advanced disease, while those with advanced HCC face limited and ineffective treatment options. Despite diagnostic efforts, no ideal tumor marker exists to date, highlighting the urgent clinical need for improved early detection of HCC. A key research objective is the development of assays that target specific pathways involved in HCC progression. This review explores the pathological origin and development of HCC, providing insights into the mechanistic rationale, clinical statistics, and the advantages and limitations of commonly used diagnostic tumor markers. Additionally, it discusses the potential of emerging biomarkers for early diagnosis and offers a brief overview of relevant assay methodologies. This review aims to summarize existing markers and investigate new ones, providing a basis for subsequent research. |
| format | Article |
| id | doaj-art-0a3ab8c31bd34fe99ad47af153c537f6 |
| institution | Kabale University |
| issn | 2542-5684 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Liver Research |
| spelling | doaj-art-0a3ab8c31bd34fe99ad47af153c537f62024-12-27T04:08:58ZengKeAi Communications Co., Ltd.Liver Research2542-56842024-12-0184218236Current status and new directions for hepatocellular carcinoma diagnosisJinqi Tu0Bo Wang1Xiaoming Wang2Kugeng Huo3Wanting Hu4Rongli Zhang5Jinyao Li6Shijie Zhu7Qionglin Liang8Shuxin Han9Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, China; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, ChinaAnimal Experimental Center, Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, China; Corresponding author. The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, China.Cyagen Biosciences (Guangzhou) Inc., Guangzhou, Guangdong, ChinaMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Lab of Microanalytical Methods & Instrumentation, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, ChinaDepartment of Medicine, Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, USAXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, ChinaDepartment of Oncology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Lab of Microanalytical Methods & Instrumentation, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, China; Corresponding author. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, China.Liver cancer ranks as the sixth most common cancer globally, with hepatocellular carcinoma (HCC) accounting for approximately 75%–85% of cases. Most patients present with moderately advanced disease, while those with advanced HCC face limited and ineffective treatment options. Despite diagnostic efforts, no ideal tumor marker exists to date, highlighting the urgent clinical need for improved early detection of HCC. A key research objective is the development of assays that target specific pathways involved in HCC progression. This review explores the pathological origin and development of HCC, providing insights into the mechanistic rationale, clinical statistics, and the advantages and limitations of commonly used diagnostic tumor markers. Additionally, it discusses the potential of emerging biomarkers for early diagnosis and offers a brief overview of relevant assay methodologies. This review aims to summarize existing markers and investigate new ones, providing a basis for subsequent research.http://www.sciencedirect.com/science/article/pii/S2542568424000680Hepatocellular carcinoma (HCC)Tumor markerEarly detectionPathological origin and development |
| spellingShingle | Jinqi Tu Bo Wang Xiaoming Wang Kugeng Huo Wanting Hu Rongli Zhang Jinyao Li Shijie Zhu Qionglin Liang Shuxin Han Current status and new directions for hepatocellular carcinoma diagnosis Liver Research Hepatocellular carcinoma (HCC) Tumor marker Early detection Pathological origin and development |
| title | Current status and new directions for hepatocellular carcinoma diagnosis |
| title_full | Current status and new directions for hepatocellular carcinoma diagnosis |
| title_fullStr | Current status and new directions for hepatocellular carcinoma diagnosis |
| title_full_unstemmed | Current status and new directions for hepatocellular carcinoma diagnosis |
| title_short | Current status and new directions for hepatocellular carcinoma diagnosis |
| title_sort | current status and new directions for hepatocellular carcinoma diagnosis |
| topic | Hepatocellular carcinoma (HCC) Tumor marker Early detection Pathological origin and development |
| url | http://www.sciencedirect.com/science/article/pii/S2542568424000680 |
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