The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons
Alleles frequencies and polymorphisms genotypes frequencies of gene DRD4 (VNTR), gene DAT (VNTR), gene 5-HTT (VNTR and ID) and gene OPRM1 (SNP) were investigated at Russian males taking narcotic substances. It was determined that genotype 4/3 occurs only at persons taking narcotic substances, the mo...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2009-06-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1862 |
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| author | Ye. V. Сherepkova I. A. Gribacheva |
| author_facet | Ye. V. Сherepkova I. A. Gribacheva |
| author_sort | Ye. V. Сherepkova |
| collection | DOAJ |
| description | Alleles frequencies and polymorphisms genotypes frequencies of gene DRD4 (VNTR), gene DAT (VNTR), gene 5-HTT (VNTR and ID) and gene OPRM1 (SNP) were investigated at Russian males taking narcotic substances. It was determined that genotype 4/3 occurs only at persons taking narcotic substances, the most often occurring polymorphism of gene DRD4 is genotype 4/4 in all groups. It was detected that the polymorphism of gene DAT at narcotized persons is presented by the high enough part of genotypes 9/10 and 10/10, but in the rest of groups the distribution is the same. At narcotized persons and in the control group, the carriers’ part of genotype I/D of gene 5НТ2А is high. The genotype D/D occurs only at persons taking narcotic substances. The genotype10/10 of gene 5НТ2А occurs more often than in population group, which conforms to the literature data. |
| format | Article |
| id | doaj-art-0a3a28de28ac43c582433198e77c4bc6 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2009-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-0a3a28de28ac43c582433198e77c4bc62025-08-20T04:00:19ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842009-06-0183(2)495410.20538/1682-0363-2009-3(2)-49-541356The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized personsYe. V. Сherepkova0I. A. Gribacheva1Научный центр клинической и экспериментальной медицины СО РАМННовосибирский государственный медицинский университетAlleles frequencies and polymorphisms genotypes frequencies of gene DRD4 (VNTR), gene DAT (VNTR), gene 5-HTT (VNTR and ID) and gene OPRM1 (SNP) were investigated at Russian males taking narcotic substances. It was determined that genotype 4/3 occurs only at persons taking narcotic substances, the most often occurring polymorphism of gene DRD4 is genotype 4/4 in all groups. It was detected that the polymorphism of gene DAT at narcotized persons is presented by the high enough part of genotypes 9/10 and 10/10, but in the rest of groups the distribution is the same. At narcotized persons and in the control group, the carriers’ part of genotype I/D of gene 5НТ2А is high. The genotype D/D occurs only at persons taking narcotic substances. The genotype10/10 of gene 5НТ2А occurs more often than in population group, which conforms to the literature data.https://bulletin.ssmu.ru/jour/article/view/1862drd4dat5нт2аoprm1 genesdrug addictionnarcomania |
| spellingShingle | Ye. V. Сherepkova I. A. Gribacheva The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons Бюллетень сибирской медицины drd4 dat 5нт2а oprm1 genes drug addiction narcomania |
| title | The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons |
| title_full | The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons |
| title_fullStr | The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons |
| title_full_unstemmed | The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons |
| title_short | The research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons |
| title_sort | research of genes series polymorphisms of brain neurotransmitter system and of the opioid reception at narcotized persons |
| topic | drd4 dat 5нт2а oprm1 genes drug addiction narcomania |
| url | https://bulletin.ssmu.ru/jour/article/view/1862 |
| work_keys_str_mv | AT yevsherepkova theresearchofgenesseriespolymorphismsofbrainneurotransmittersystemandoftheopioidreceptionatnarcotizedpersons AT iagribacheva theresearchofgenesseriespolymorphismsofbrainneurotransmittersystemandoftheopioidreceptionatnarcotizedpersons AT yevsherepkova researchofgenesseriespolymorphismsofbrainneurotransmittersystemandoftheopioidreceptionatnarcotizedpersons AT iagribacheva researchofgenesseriespolymorphismsofbrainneurotransmittersystemandoftheopioidreceptionatnarcotizedpersons |