Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures
<b>Background</b>: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify...
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MDPI AG
2024-11-01
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| author | Daniel Ricardo Delgado Jennifer Katiusca Castro-Camacho Claudia Patricia Ortiz Diego Ivan Caviedes-Rubio Fleming Martinez |
| author_facet | Daniel Ricardo Delgado Jennifer Katiusca Castro-Camacho Claudia Patricia Ortiz Diego Ivan Caviedes-Rubio Fleming Martinez |
| author_sort | Daniel Ricardo Delgado |
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| description | <b>Background</b>: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the dissolution process. The aim of this research is to evaluate the solubility of sulfamethazine in acetotinitrile + 1-propanol cosolvent mixtures at 9 temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, and 318.15 K); a drug used in human and veterinary therapy and two solvents of great chemical–pharmaceutical interest. <b>Methods</b>: The determination was carried out by the shaking flask method and the drug was quantified by UV/Vis spectrophotometry. <b>Results</b>: The solubility of sulfamethazine increases from pure 1-propanol (solvent in which it reaches its lowest solubility at 278.15 K) to pure acetonitrile (solvent in which it reaches its maximum solubility at 318.15 K), behaving in a logarithmic-linear fashion. <b>Conclusions</b>: The increase in solubility is related to the acid/base character of the cosolvent mixtures and not to the solubility parameter of the mixtures. The dissolution process is endothermic and favored by the solution entropy, and also shows a strong entropic compensation. |
| format | Article |
| id | doaj-art-0a38d42153be4e869cf3c5644b39c634 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-11-01 |
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| spelling | doaj-art-0a38d42153be4e869cf3c5644b39c6342024-12-27T14:45:48ZengMDPI AGPharmaceuticals1424-82472024-11-011712159410.3390/ph17121594Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) MixturesDaniel Ricardo Delgado0Jennifer Katiusca Castro-Camacho1Claudia Patricia Ortiz2Diego Ivan Caviedes-Rubio3Fleming Martinez4Programa de Ingeniería Civil, Grupo de Investigación de Ingenierías UCC-Neiva, Facultad de Ingeniería, Universidad Cooperativa de Colombia, Sede Neiva, Calle 11 No. 1-51, Neiva 410001, Huila, ColombiaPrograma de Ingeniería Agroindustrial, Hidroingeniería y Desarrollo Agropecuario, Facultad de Ingeniería, Universidad Surcolombiana, Neiva 410001, Huila, ColombiaPrograma de Administración en Seguridad y Salud en el Trabajo, Grupo de Investigación en Seguridad y Salud en el Trabajo, Corporación Universitaria Minuto de Dios-UNIMINUTO, Neiva 410001, Huila, ColombiaPrograma de Ingeniería Civil, Grupo de Investigación de Ingenierías UCC-Neiva, Facultad de Ingeniería, Universidad Cooperativa de Colombia, Sede Neiva, Calle 11 No. 1-51, Neiva 410001, Huila, ColombiaGrupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Carrera 30 No. 45-03, Bogotá 110321, Cundinamarca, Colombia<b>Background</b>: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the dissolution process. The aim of this research is to evaluate the solubility of sulfamethazine in acetotinitrile + 1-propanol cosolvent mixtures at 9 temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, and 318.15 K); a drug used in human and veterinary therapy and two solvents of great chemical–pharmaceutical interest. <b>Methods</b>: The determination was carried out by the shaking flask method and the drug was quantified by UV/Vis spectrophotometry. <b>Results</b>: The solubility of sulfamethazine increases from pure 1-propanol (solvent in which it reaches its lowest solubility at 278.15 K) to pure acetonitrile (solvent in which it reaches its maximum solubility at 318.15 K), behaving in a logarithmic-linear fashion. <b>Conclusions</b>: The increase in solubility is related to the acid/base character of the cosolvent mixtures and not to the solubility parameter of the mixtures. The dissolution process is endothermic and favored by the solution entropy, and also shows a strong entropic compensation.https://www.mdpi.com/1424-8247/17/12/1594sulfamethazinesolubilityacetonitrile1-propanolcosolvencysolution thermodynamics |
| spellingShingle | Daniel Ricardo Delgado Jennifer Katiusca Castro-Camacho Claudia Patricia Ortiz Diego Ivan Caviedes-Rubio Fleming Martinez Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures Pharmaceuticals sulfamethazine solubility acetonitrile 1-propanol cosolvency solution thermodynamics |
| title | Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures |
| title_full | Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures |
| title_fullStr | Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures |
| title_full_unstemmed | Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures |
| title_short | Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures |
| title_sort | dissolution thermodynamics of the solubility of sulfamethazine in acetonitrile 1 propanol mixtures |
| topic | sulfamethazine solubility acetonitrile 1-propanol cosolvency solution thermodynamics |
| url | https://www.mdpi.com/1424-8247/17/12/1594 |
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