Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery—a scoping review
IntroductionThe relationship between the Enhanced Recovery After Surgery (ERAS) guidelines and inflammatory markers in laparoscopic surgery has garnered increasing attention. These recommendations are designed to minimize surgical stress and potentially improve recovery outcomes by modifying periope...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2024.1450434/full |
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| author | Carlos Darcy Alves Bersot Carlos Darcy Alves Bersot Lucas Ferreira Gomes Pereira Lucas Ferreira Gomes Pereira Victor Gabriel Vieira Goncho Victor Gabriel Vieira Goncho José Eduardo Guimarães Pereira Luiz Fernando dos Reis Falcão Luiz Fernando dos Reis Falcão |
| author_facet | Carlos Darcy Alves Bersot Carlos Darcy Alves Bersot Lucas Ferreira Gomes Pereira Lucas Ferreira Gomes Pereira Victor Gabriel Vieira Goncho Victor Gabriel Vieira Goncho José Eduardo Guimarães Pereira Luiz Fernando dos Reis Falcão Luiz Fernando dos Reis Falcão |
| author_sort | Carlos Darcy Alves Bersot |
| collection | DOAJ |
| description | IntroductionThe relationship between the Enhanced Recovery After Surgery (ERAS) guidelines and inflammatory markers in laparoscopic surgery has garnered increasing attention. These recommendations are designed to minimize surgical stress and potentially improve recovery outcomes by modifying perioperative care.ObjectiveThis scoping review aims to evaluate the impact of ERAS recommendations on inflammatory markers in patients undergoing laparoscopic surgeries, identifying current research gaps and consolidating findings from existing studies.MethodsGuided by the Cochrane Handbook for Systematic Reviews and adhering to the PRISMA-ScR guidelines, this review analyzed studies from databases like PubMed, Scopus, and Cochrane Library. We included both randomized controlled trials and observational studies that assessed inflammatory markers such as C-reactive protein (CRP), white blood cells (WBC), and Interleukin-6 (IL-6) in laparoscopic surgery patients managed with ERAS recommendations.ResultsOut of 64 initial studies, 7 met the inclusion criteria, involving a total of 2,047 patients. Most of the studies focused on laparoscopic colorectal surgeries. Commonly assessed markers were CRP and WBC. The findings consistently showed that ERAS guideline could mitigate the inflammatory response, evidenced by reduced levels of CRP and IL-6, which correlated with fewer postoperative complications and expedited recovery.ConclusionERAS recommendations appear to beneficially modulate inflammatory responses in laparoscopic surgery, which suggests a potential for enhanced recovery outcomes. However, the evidence is currently limited by the small number of studies and inherent methodological biases. Further robust RCTs are required to strengthen the evidence base and refine these protocols for broader clinical application.
Systematic Review Registrationhttps://osf.io/tj8mw/ |
| format | Article |
| id | doaj-art-0a36db7b16e941e28a22fface0c4a129 |
| institution | Kabale University |
| issn | 2296-875X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj-art-0a36db7b16e941e28a22fface0c4a1292024-12-09T06:28:53ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2024-12-011110.3389/fsurg.2024.14504341450434Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery—a scoping reviewCarlos Darcy Alves Bersot0Carlos Darcy Alves Bersot1Lucas Ferreira Gomes Pereira2Lucas Ferreira Gomes Pereira3Victor Gabriel Vieira Goncho4Victor Gabriel Vieira Goncho5José Eduardo Guimarães Pereira6Luiz Fernando dos Reis Falcão7Luiz Fernando dos Reis Falcão8Department of Anesthesia, BP Hospital – A Beneficência Portuguesa de São Paulo (Anextesia), São Paulo, BrazilPostgraduate in Translational Medicine of the Paulista School of Medicine, EPM-UNIFESP, São Paulo, BrazilDepartment of Anesthesia, BP Hospital – A Beneficência Portuguesa de São Paulo (Anextesia), São Paulo, BrazilDiscipline of Anesthesiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilDepartment of Anesthesia, BP Hospital – A Beneficência Portuguesa de São Paulo (Anextesia), São Paulo, BrazilPostgraduate in Translational Medicine of the Paulista School of Medicine, EPM-UNIFESP, São Paulo, BrazilDepartment of Anesthesiology, Hospital Unimed Volta Redonda, Rio de Janeiro, BrazilDepartment of Anesthesia, BP Hospital – A Beneficência Portuguesa de São Paulo (Anextesia), São Paulo, BrazilDepartment of Anesthesiology, Pain and Critical Care Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, BrazilIntroductionThe relationship between the Enhanced Recovery After Surgery (ERAS) guidelines and inflammatory markers in laparoscopic surgery has garnered increasing attention. These recommendations are designed to minimize surgical stress and potentially improve recovery outcomes by modifying perioperative care.ObjectiveThis scoping review aims to evaluate the impact of ERAS recommendations on inflammatory markers in patients undergoing laparoscopic surgeries, identifying current research gaps and consolidating findings from existing studies.MethodsGuided by the Cochrane Handbook for Systematic Reviews and adhering to the PRISMA-ScR guidelines, this review analyzed studies from databases like PubMed, Scopus, and Cochrane Library. We included both randomized controlled trials and observational studies that assessed inflammatory markers such as C-reactive protein (CRP), white blood cells (WBC), and Interleukin-6 (IL-6) in laparoscopic surgery patients managed with ERAS recommendations.ResultsOut of 64 initial studies, 7 met the inclusion criteria, involving a total of 2,047 patients. Most of the studies focused on laparoscopic colorectal surgeries. Commonly assessed markers were CRP and WBC. The findings consistently showed that ERAS guideline could mitigate the inflammatory response, evidenced by reduced levels of CRP and IL-6, which correlated with fewer postoperative complications and expedited recovery.ConclusionERAS recommendations appear to beneficially modulate inflammatory responses in laparoscopic surgery, which suggests a potential for enhanced recovery outcomes. However, the evidence is currently limited by the small number of studies and inherent methodological biases. Further robust RCTs are required to strengthen the evidence base and refine these protocols for broader clinical application. Systematic Review Registrationhttps://osf.io/tj8mw/https://www.frontiersin.org/articles/10.3389/fsurg.2024.1450434/fullenhanced recovery after surgeryinflammationlaparoscopyanesthesiasurgery |
| spellingShingle | Carlos Darcy Alves Bersot Carlos Darcy Alves Bersot Lucas Ferreira Gomes Pereira Lucas Ferreira Gomes Pereira Victor Gabriel Vieira Goncho Victor Gabriel Vieira Goncho José Eduardo Guimarães Pereira Luiz Fernando dos Reis Falcão Luiz Fernando dos Reis Falcão Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery—a scoping review Frontiers in Surgery enhanced recovery after surgery inflammation laparoscopy anesthesia surgery |
| title | Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery—a scoping review |
| title_full | Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery—a scoping review |
| title_fullStr | Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery—a scoping review |
| title_full_unstemmed | Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery—a scoping review |
| title_short | Enhancing recovery and reducing inflammation: the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery—a scoping review |
| title_sort | enhancing recovery and reducing inflammation the impact of enhanced recovery after surgery recommendations on inflammatory markers in laparoscopic surgery a scoping review |
| topic | enhanced recovery after surgery inflammation laparoscopy anesthesia surgery |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2024.1450434/full |
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