Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016
Abstract Insulin resistance (IR) and abdominal obesity are key in osteoarthritis (OA) development. The triglyceride glucose (TyG) index, along with indicators such as the visceral adiposity index (VAI), and lipid accumulation product (LAP), are increasingly used to measure IR. This study aims to exp...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84317-z |
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| author | Youmian Lan Qiongbing Zheng Meijing Li Jiexin Chen Dongyang Huang Ling Lin |
| author_facet | Youmian Lan Qiongbing Zheng Meijing Li Jiexin Chen Dongyang Huang Ling Lin |
| author_sort | Youmian Lan |
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| description | Abstract Insulin resistance (IR) and abdominal obesity are key in osteoarthritis (OA) development. The triglyceride glucose (TyG) index, along with indicators such as the visceral adiposity index (VAI), and lipid accumulation product (LAP), are increasingly used to measure IR. This study aims to explore the associations between surrogate IR indexes and OA, assessing their diagnostic efficacy within American populations. This study included 14,715 adults from the National Health and Nutrition Examination Survey 2003–2016. Logistic regression models and restricted cubic spline were used to explore the relationship between surrogate IR indexes and OA. Receiver operating characteristic curves were constructed to assess the diagnostic efficacy of these indices, with the area under the curve (AUC) as the metric. TyG, glucose triglyceride-waist circumference (TyG-WC), glucose triglyceride-body mass index (TyG-BMI), glucose triglyceride-waist height ratio (TyG-WHtR), VAI and LAP were significantly and positively associated with the prevalence of OA (all p < 0.01). After adjusting for various potential confounders, TyG-WC, TyG-BMI, TyG-WHtR and LAP remained significantly correlated with the prevalence of OA. Furthermore, restricted cubic spline revealed a nonlinear association between TyG-BMI, TyG-WHtR and LAP (all P-non-linear < 0.05). Receiver operating characteristic curves indicated that TyG-WHtR (AUC 0.633) demonstrated more robust diagnostic efficacy. Additionally, the sensitivity analysis produced results consistent with the primary findings. TyG and its combination with obesity indicators and LAP, are positively associated with the prevalence of OA, with TyG-WHtR showing the highest diagnostic efficacy. |
| format | Article |
| id | doaj-art-0a1b23cc35f64d11ac8f6708c9e6befe |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-0a1b23cc35f64d11ac8f6708c9e6befe2025-01-12T12:22:22ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-024-84317-zAssociations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016Youmian Lan0Qiongbing Zheng1Meijing Li2Jiexin Chen3Dongyang Huang4Ling Lin5Department of Rheumatology and Immunology, The First Affiliated Hospital of Shantou University Medical CollegeDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Shantou University Medical CollegeDepartment of Cell Biology and Genetics, Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Shantou University Medical CollegeDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Shantou University Medical CollegeDepartment of Cell Biology and Genetics, Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes, Shantou University Medical CollegeDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Shantou University Medical CollegeAbstract Insulin resistance (IR) and abdominal obesity are key in osteoarthritis (OA) development. The triglyceride glucose (TyG) index, along with indicators such as the visceral adiposity index (VAI), and lipid accumulation product (LAP), are increasingly used to measure IR. This study aims to explore the associations between surrogate IR indexes and OA, assessing their diagnostic efficacy within American populations. This study included 14,715 adults from the National Health and Nutrition Examination Survey 2003–2016. Logistic regression models and restricted cubic spline were used to explore the relationship between surrogate IR indexes and OA. Receiver operating characteristic curves were constructed to assess the diagnostic efficacy of these indices, with the area under the curve (AUC) as the metric. TyG, glucose triglyceride-waist circumference (TyG-WC), glucose triglyceride-body mass index (TyG-BMI), glucose triglyceride-waist height ratio (TyG-WHtR), VAI and LAP were significantly and positively associated with the prevalence of OA (all p < 0.01). After adjusting for various potential confounders, TyG-WC, TyG-BMI, TyG-WHtR and LAP remained significantly correlated with the prevalence of OA. Furthermore, restricted cubic spline revealed a nonlinear association between TyG-BMI, TyG-WHtR and LAP (all P-non-linear < 0.05). Receiver operating characteristic curves indicated that TyG-WHtR (AUC 0.633) demonstrated more robust diagnostic efficacy. Additionally, the sensitivity analysis produced results consistent with the primary findings. TyG and its combination with obesity indicators and LAP, are positively associated with the prevalence of OA, with TyG-WHtR showing the highest diagnostic efficacy.https://doi.org/10.1038/s41598-024-84317-zOsteoarthritisInsulin resistanceTriglyceride glucoseTyG-WHtRNHANES |
| spellingShingle | Youmian Lan Qiongbing Zheng Meijing Li Jiexin Chen Dongyang Huang Ling Lin Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016 Scientific Reports Osteoarthritis Insulin resistance Triglyceride glucose TyG-WHtR NHANES |
| title | Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016 |
| title_full | Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016 |
| title_fullStr | Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016 |
| title_full_unstemmed | Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016 |
| title_short | Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003–2016 |
| title_sort | associations between surrogate insulin resistance indexes and osteoarthritis nhanes 2003 2016 |
| topic | Osteoarthritis Insulin resistance Triglyceride glucose TyG-WHtR NHANES |
| url | https://doi.org/10.1038/s41598-024-84317-z |
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