Probiotics Enhance FOLFOX Efficacy Via Gut Bacterial Tryptophan Metabolism in Colorectal Cancer
FOLFOX is the recommended regimen for CRC chemotherapy, but its response rate is limited. Our previous studies confirmed that intestinal microbiota is strongly associated with FOLFOX's anti-CRC effect, but the underlying mechanism remains unclear. In this study, we investigated the effects and...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2024/61/bioconf_isaeb2024_03003.pdf |
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| author | Deng Yufei Hou Xiaoying Chen Kailing Shao Tong Liu Yuchen |
| author_facet | Deng Yufei Hou Xiaoying Chen Kailing Shao Tong Liu Yuchen |
| author_sort | Deng Yufei |
| collection | DOAJ |
| description | FOLFOX is the recommended regimen for CRC chemotherapy, but its response rate is limited. Our previous studies confirmed that intestinal microbiota is strongly associated with FOLFOX's anti-CRC effect, but the underlying mechanism remains unclear. In this study, we investigated the effects and potential mechanisms of complex-probiotics on FOLFOX efficacy against CRC based on microbiome and metabolomics analysis. We found that probiotics enhanced FOLFOX's anticancer activity, greatly changed the distribution of gut microbiota and metabolic activity of tumor-bearing mice. Further analysis revealed that level of gut bacterial tryptophan metabolism was significantly correlated with pharmacodynamic indexes of FOLFOX, demonstrating that probiotics may enhance FOLFOX efficacy through gut microbiota tryptophan metabolism. This study provides novel insights as well as potential synergistic strategy of FOLFOX in clinical CRC treatment. |
| format | Article |
| id | doaj-art-0a13376295a7409a95ab56c276575f8c |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-0a13376295a7409a95ab56c276575f8c2024-12-06T09:32:09ZengEDP SciencesBIO Web of Conferences2117-44582024-01-011420300310.1051/bioconf/202414203003bioconf_isaeb2024_03003Probiotics Enhance FOLFOX Efficacy Via Gut Bacterial Tryptophan Metabolism in Colorectal CancerDeng Yufei0Hou Xiaoying1Chen Kailing2Shao Tong3Liu Yuchen4Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan UniversityHubei Key Laboratory of Cognitive and Affective Disorders, Jianghan UniversityInstitute of Biomedical Sciences, School of Medicine, Jianghan UniversityInstitute of Biomedical Sciences, School of Medicine, Jianghan UniversityHubei Key Laboratory of Cognitive and Affective Disorders, Jianghan UniversityFOLFOX is the recommended regimen for CRC chemotherapy, but its response rate is limited. Our previous studies confirmed that intestinal microbiota is strongly associated with FOLFOX's anti-CRC effect, but the underlying mechanism remains unclear. In this study, we investigated the effects and potential mechanisms of complex-probiotics on FOLFOX efficacy against CRC based on microbiome and metabolomics analysis. We found that probiotics enhanced FOLFOX's anticancer activity, greatly changed the distribution of gut microbiota and metabolic activity of tumor-bearing mice. Further analysis revealed that level of gut bacterial tryptophan metabolism was significantly correlated with pharmacodynamic indexes of FOLFOX, demonstrating that probiotics may enhance FOLFOX efficacy through gut microbiota tryptophan metabolism. This study provides novel insights as well as potential synergistic strategy of FOLFOX in clinical CRC treatment.https://www.bio-conferences.org/articles/bioconf/pdf/2024/61/bioconf_isaeb2024_03003.pdf |
| spellingShingle | Deng Yufei Hou Xiaoying Chen Kailing Shao Tong Liu Yuchen Probiotics Enhance FOLFOX Efficacy Via Gut Bacterial Tryptophan Metabolism in Colorectal Cancer BIO Web of Conferences |
| title | Probiotics Enhance FOLFOX Efficacy Via Gut Bacterial Tryptophan Metabolism in Colorectal Cancer |
| title_full | Probiotics Enhance FOLFOX Efficacy Via Gut Bacterial Tryptophan Metabolism in Colorectal Cancer |
| title_fullStr | Probiotics Enhance FOLFOX Efficacy Via Gut Bacterial Tryptophan Metabolism in Colorectal Cancer |
| title_full_unstemmed | Probiotics Enhance FOLFOX Efficacy Via Gut Bacterial Tryptophan Metabolism in Colorectal Cancer |
| title_short | Probiotics Enhance FOLFOX Efficacy Via Gut Bacterial Tryptophan Metabolism in Colorectal Cancer |
| title_sort | probiotics enhance folfox efficacy via gut bacterial tryptophan metabolism in colorectal cancer |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2024/61/bioconf_isaeb2024_03003.pdf |
| work_keys_str_mv | AT dengyufei probioticsenhancefolfoxefficacyviagutbacterialtryptophanmetabolismincolorectalcancer AT houxiaoying probioticsenhancefolfoxefficacyviagutbacterialtryptophanmetabolismincolorectalcancer AT chenkailing probioticsenhancefolfoxefficacyviagutbacterialtryptophanmetabolismincolorectalcancer AT shaotong probioticsenhancefolfoxefficacyviagutbacterialtryptophanmetabolismincolorectalcancer AT liuyuchen probioticsenhancefolfoxefficacyviagutbacterialtryptophanmetabolismincolorectalcancer |