Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)
Abstract Severe community-acquired pneumonia (SCAP) is a serious respiratory inflammation disease with high morbidity and mortality. This study aimed to evaluate the prognostic value of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR),...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80727-1 |
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| author | Xiao-Jiao Cui Bo Xie Ke-Wei Zhu Qian-Qian Liao Jian-Cheng Zhou Shan Du Xin-Xia Liu Zhu-Jun Chen Yong Yang Xiaoqing Yi |
| author_facet | Xiao-Jiao Cui Bo Xie Ke-Wei Zhu Qian-Qian Liao Jian-Cheng Zhou Shan Du Xin-Xia Liu Zhu-Jun Chen Yong Yang Xiaoqing Yi |
| author_sort | Xiao-Jiao Cui |
| collection | DOAJ |
| description | Abstract Severe community-acquired pneumonia (SCAP) is a serious respiratory inflammation disease with high morbidity and mortality. This study aimed to evaluate the prognostic value of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR) and eosinophil-to-lymphocyte ratio (ELR) in patients with SCAP. The study retrospectively included 554 patients with SCAP, and the clinical data were obtained from the electronic patient record (EMR) system. The primary outcome was in-hospital mortality, and the secondary outcomes included hospital length of stay (LOS), overall survival (OS), admission to ICU, ICU LOS, and ICU mortality. The results showed that both NLR and BLR were significant but not independent prognostic factors for in-hospital mortality; NLR was negatively correlated with hospital LOS while ELR was positively correlated with hospital LOS; both increased NLR and increased BLR were associated with reduced OS, while increased ELR was associated with improved OS; increased PLR, NLR, MLR, and BLR were all correlated with elevated ICU admission rates, while increased ELR was correlated with a reduced ICU admission rate; ELR was positively correlated with ICU LOS; both higher NLR and higher BLR were associated with increased ICU mortality. In summary, NLR and BLR were useful prognostic factors for clinical outcomes in patients with SCAP. |
| format | Article |
| id | doaj-art-0a0e2d91bbc74671ac2b668b0af431a5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-0a0e2d91bbc74671ac2b668b0af431a52024-12-08T12:27:25ZengNature PortfolioScientific Reports2045-23222024-12-0114112110.1038/s41598-024-80727-1Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)Xiao-Jiao Cui0Bo Xie1Ke-Wei Zhu2Qian-Qian Liao3Jian-Cheng Zhou4Shan Du5Xin-Xia Liu6Zhu-Jun Chen7Yong Yang8Xiaoqing Yi9Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Cardiology, Chengdu First People’s HospitalOffice of Pharmacovigilance, GuangZhou BaiYunShan Pharmaceutical Holdings Co.,Ltd, BaiYunShan Pharmaceutical General FactoryDepartment of Pharmacy, People’s Hospital of GuilinDepartment of Pharmacy, Jiangsu Province HospitalDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaAbstract Severe community-acquired pneumonia (SCAP) is a serious respiratory inflammation disease with high morbidity and mortality. This study aimed to evaluate the prognostic value of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR) and eosinophil-to-lymphocyte ratio (ELR) in patients with SCAP. The study retrospectively included 554 patients with SCAP, and the clinical data were obtained from the electronic patient record (EMR) system. The primary outcome was in-hospital mortality, and the secondary outcomes included hospital length of stay (LOS), overall survival (OS), admission to ICU, ICU LOS, and ICU mortality. The results showed that both NLR and BLR were significant but not independent prognostic factors for in-hospital mortality; NLR was negatively correlated with hospital LOS while ELR was positively correlated with hospital LOS; both increased NLR and increased BLR were associated with reduced OS, while increased ELR was associated with improved OS; increased PLR, NLR, MLR, and BLR were all correlated with elevated ICU admission rates, while increased ELR was correlated with a reduced ICU admission rate; ELR was positively correlated with ICU LOS; both higher NLR and higher BLR were associated with increased ICU mortality. In summary, NLR and BLR were useful prognostic factors for clinical outcomes in patients with SCAP.https://doi.org/10.1038/s41598-024-80727-1Platelet-to-lymphocyte ratio (PLR)Neutrophil-to-lymphocyte ratio (NLR)Monocyte-to-lymphocyte ratio (MLR)Basophil-to-lymphocyte ratio (BLR)Eosinophil-to-lymphocyte ratio (ELR)Healthy volunteer |
| spellingShingle | Xiao-Jiao Cui Bo Xie Ke-Wei Zhu Qian-Qian Liao Jian-Cheng Zhou Shan Du Xin-Xia Liu Zhu-Jun Chen Yong Yang Xiaoqing Yi Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP) Scientific Reports Platelet-to-lymphocyte ratio (PLR) Neutrophil-to-lymphocyte ratio (NLR) Monocyte-to-lymphocyte ratio (MLR) Basophil-to-lymphocyte ratio (BLR) Eosinophil-to-lymphocyte ratio (ELR) Healthy volunteer |
| title | Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP) |
| title_full | Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP) |
| title_fullStr | Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP) |
| title_full_unstemmed | Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP) |
| title_short | Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP) |
| title_sort | prognostic value of the platelet neutrophil monocyte basophil and eosinophil to lymphocyte ratios in patients with severe community acquired pneumonia scap |
| topic | Platelet-to-lymphocyte ratio (PLR) Neutrophil-to-lymphocyte ratio (NLR) Monocyte-to-lymphocyte ratio (MLR) Basophil-to-lymphocyte ratio (BLR) Eosinophil-to-lymphocyte ratio (ELR) Healthy volunteer |
| url | https://doi.org/10.1038/s41598-024-80727-1 |
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