Advances in liver engineering with cell, scaffold, and vascularization
Liver tissue engineering is a promising alternative to organ transplantation for the treatment of end-stage liver disease, acute liver failure, and liver-based metabolic disorders. This review discusses the current progress and obstacles in tissue engineering of cell sources, biomaterials, and vascu...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | EngMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950489924000411 |
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| _version_ | 1841545879395237888 |
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| author | Chunyan Liu Yulian Wang Xuqian Zhou Lei Dong |
| author_facet | Chunyan Liu Yulian Wang Xuqian Zhou Lei Dong |
| author_sort | Chunyan Liu |
| collection | DOAJ |
| description | Liver tissue engineering is a promising alternative to organ transplantation for the treatment of end-stage liver disease, acute liver failure, and liver-based metabolic disorders. This review discusses the current progress and obstacles in tissue engineering of cell sources, biomaterials, and vascularization strategies, which are key to constructing functional liver tissues. Significant progress has been made in developing available cell sources, tunable biomaterials, and integrating vascular networks. However, challenges remain in replicating the complex architecture and function of the liver. Further research is required to overcome these hurdles and ultimately realize the full potential of tissue-engineered liver constructs in clinical applications. |
| format | Article |
| id | doaj-art-0a077759a0754fc6aefe9c20e642f83d |
| institution | Kabale University |
| issn | 2950-4899 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EngMedicine |
| spelling | doaj-art-0a077759a0754fc6aefe9c20e642f83d2025-01-11T06:42:30ZengElsevierEngMedicine2950-48992024-12-0113100041Advances in liver engineering with cell, scaffold, and vascularizationChunyan Liu0Yulian Wang1Xuqian Zhou2Lei Dong3State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, ChinaState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, ChinaState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, ChinaState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, China; Chemistry and Biomedicine Innovative Center, Nanjing University, Nanjing, Jiangsu, China; Corresponding author. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, China.Liver tissue engineering is a promising alternative to organ transplantation for the treatment of end-stage liver disease, acute liver failure, and liver-based metabolic disorders. This review discusses the current progress and obstacles in tissue engineering of cell sources, biomaterials, and vascularization strategies, which are key to constructing functional liver tissues. Significant progress has been made in developing available cell sources, tunable biomaterials, and integrating vascular networks. However, challenges remain in replicating the complex architecture and function of the liver. Further research is required to overcome these hurdles and ultimately realize the full potential of tissue-engineered liver constructs in clinical applications.http://www.sciencedirect.com/science/article/pii/S2950489924000411Liver tissue engineeringReprogrammed cellsEngineered scaffoldVascularization |
| spellingShingle | Chunyan Liu Yulian Wang Xuqian Zhou Lei Dong Advances in liver engineering with cell, scaffold, and vascularization EngMedicine Liver tissue engineering Reprogrammed cells Engineered scaffold Vascularization |
| title | Advances in liver engineering with cell, scaffold, and vascularization |
| title_full | Advances in liver engineering with cell, scaffold, and vascularization |
| title_fullStr | Advances in liver engineering with cell, scaffold, and vascularization |
| title_full_unstemmed | Advances in liver engineering with cell, scaffold, and vascularization |
| title_short | Advances in liver engineering with cell, scaffold, and vascularization |
| title_sort | advances in liver engineering with cell scaffold and vascularization |
| topic | Liver tissue engineering Reprogrammed cells Engineered scaffold Vascularization |
| url | http://www.sciencedirect.com/science/article/pii/S2950489924000411 |
| work_keys_str_mv | AT chunyanliu advancesinliverengineeringwithcellscaffoldandvascularization AT yulianwang advancesinliverengineeringwithcellscaffoldandvascularization AT xuqianzhou advancesinliverengineeringwithcellscaffoldandvascularization AT leidong advancesinliverengineeringwithcellscaffoldandvascularization |