A patient with long-term diabetes dies following infection with Francisella novicida in Guangdong province, China: a case report
Abstract. The rarity of Francisella novicida infection in humans is well-known, and the F. novicida cases occur in immunocompromised patients or those with underlying health problems. Herein, we report the case of a patient with long-term diabetes who died following F. novicida infection that caused...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health - Lippincott Williams Wilkins
2025-01-01
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| Series: | Infectious Diseases & Immunity |
| Online Access: | http://journals.lww.com/10.1097/ID9.0000000000000147 |
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| author | Linjin Fan Jialong Guan Lizhi Feng Yulong Wang Huimin Zeng Ying Zhu Hao Li Qiang Chen Linghua Li Jun Qian Linna Liu Yueping Li Wei Zhao |
| author_facet | Linjin Fan Jialong Guan Lizhi Feng Yulong Wang Huimin Zeng Ying Zhu Hao Li Qiang Chen Linghua Li Jun Qian Linna Liu Yueping Li Wei Zhao |
| author_sort | Linjin Fan |
| collection | DOAJ |
| description | Abstract. The rarity of Francisella novicida infection in humans is well-known, and the F. novicida cases occur in immunocompromised patients or those with underlying health problems. Herein, we report the case of a patient with long-term diabetes who died following F. novicida infection that caused multiple organ failure, although F. novicida was effectively eliminated using antimicrobial therapy. Microbiological confirmation of F. novicida infection relies on metagenomic next-generation sequencing (mNGS) and pdpD-2 gene-specific identification. This study highlights the importance of early pathogen diagnosis in severely infected patients, particularly in cases of F. novicida, and indicates that mNGS is a useful tool for early diagnosis. |
| format | Article |
| id | doaj-art-09ef9bbd9f1a4c7d9423f128e2cd011c |
| institution | Kabale University |
| issn | 2096-9511 2693-8839 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | Infectious Diseases & Immunity |
| spelling | doaj-art-09ef9bbd9f1a4c7d9423f128e2cd011c2025-01-14T07:30:25ZengWolters Kluwer Health - Lippincott Williams WilkinsInfectious Diseases & Immunity2096-95112693-88392025-01-0151687110.1097/ID9.0000000000000147202501000-00008A patient with long-term diabetes dies following infection with Francisella novicida in Guangdong province, China: a case reportLinjin Fan0Jialong Guan1Lizhi Feng2Yulong Wang3Huimin Zeng4Ying Zhu5Hao Li6Qiang Chen7Linghua Li8Jun Qian9Linna Liu10Yueping Li11Wei Zhao1 Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, China1 Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, China1 Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, China2 Institute of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510442, ChinaAbstract. The rarity of Francisella novicida infection in humans is well-known, and the F. novicida cases occur in immunocompromised patients or those with underlying health problems. Herein, we report the case of a patient with long-term diabetes who died following F. novicida infection that caused multiple organ failure, although F. novicida was effectively eliminated using antimicrobial therapy. Microbiological confirmation of F. novicida infection relies on metagenomic next-generation sequencing (mNGS) and pdpD-2 gene-specific identification. This study highlights the importance of early pathogen diagnosis in severely infected patients, particularly in cases of F. novicida, and indicates that mNGS is a useful tool for early diagnosis.http://journals.lww.com/10.1097/ID9.0000000000000147 |
| spellingShingle | Linjin Fan Jialong Guan Lizhi Feng Yulong Wang Huimin Zeng Ying Zhu Hao Li Qiang Chen Linghua Li Jun Qian Linna Liu Yueping Li Wei Zhao A patient with long-term diabetes dies following infection with Francisella novicida in Guangdong province, China: a case report Infectious Diseases & Immunity |
| title | A patient with long-term diabetes dies following infection with Francisella novicida in Guangdong province, China: a case report |
| title_full | A patient with long-term diabetes dies following infection with Francisella novicida in Guangdong province, China: a case report |
| title_fullStr | A patient with long-term diabetes dies following infection with Francisella novicida in Guangdong province, China: a case report |
| title_full_unstemmed | A patient with long-term diabetes dies following infection with Francisella novicida in Guangdong province, China: a case report |
| title_short | A patient with long-term diabetes dies following infection with Francisella novicida in Guangdong province, China: a case report |
| title_sort | patient with long term diabetes dies following infection with francisella novicida in guangdong province china a case report |
| url | http://journals.lww.com/10.1097/ID9.0000000000000147 |
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