Environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment, bisphenol A sensing and nursing applications: Fabrication, characterization and ANN modeling
This study presents a dual application approach for the environmentally friendly synthesis of gelatin hydrogel nanoparticles with potential applications in gastric cancer treatment, bisphenol A (BPA) sensing, and nursing. Gelatin hydrogel nanoparticles were synthesized using a green and freeze-dryin...
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Elsevier
2024-12-01
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| author | Sun Qian Ruiyan Xu |
| author_facet | Sun Qian Ruiyan Xu |
| author_sort | Sun Qian |
| collection | DOAJ |
| description | This study presents a dual application approach for the environmentally friendly synthesis of gelatin hydrogel nanoparticles with potential applications in gastric cancer treatment, bisphenol A (BPA) sensing, and nursing. Gelatin hydrogel nanoparticles were synthesized using a green and freeze-drying method, avoiding the use of toxic chemicals and solvents. The nanoparticles showed excellent biocompatibility and promising potential for drug delivery system (DDS) in gastric cancer treatment. The controlled release of anticancer drugs from the gelatin nanoparticles was showed, highlighting their potential in targeted therapy. Additionally, the gelatin hydrogel nanoparticles were explored for BPA sensing. BPA is a widely used chemical known for its adverse effects on human health. The gelatin nanoparticles showed high selectivity and sensitivity towards BPA detection, making them suitable for environmental monitoring and health applications using scanning electron microscope (SEM). Also, in this study, an artificial neural network (ANN) was used to estimate the release of docetaxel (%) at 72 h, the release of paclitaxel (%) at 72 h, tensile strength with sample (wt%), and porosity (%) in broader ranges than the experimental samples. The environmentally friendly synthesis of gelatin hydrogel nanoparticles presented in this study offers a versatile platform with dual applications in gastric cancer treatment and sensing of harmful chemicals. The obtained results show the potential of these nanoparticles for innovative therapeutic and diagnostic strategies in healthcare and environmental monitoring. The study showed the development of sustainable and multifunctional nanomaterials for various biomedical applications. The modeling of the neural network predictions shows that increasing the sample (wt%) and porosity (%) leads to an increase in the release of docetaxel (%) at 72 h, the release of paclitaxel (%) at 72 h, and tensile strength. As porosity decreases, the release of docetaxel increases, and the release of paclitaxel and tensile strength also increase. Additionally, the prediction errors of the ANN in this study were evaluated using linear regression, showing acceptable error rates compared to the target results obtained from the experimental tests. |
| format | Article |
| id | doaj-art-09e4907872a044d79cd4565b227d6c5d |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-09e4907872a044d79cd4565b227d6c5d2024-12-13T10:58:15ZengElsevierHeliyon2405-84402024-12-011023e38834Environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment, bisphenol A sensing and nursing applications: Fabrication, characterization and ANN modelingSun Qian0Ruiyan Xu1Gastroenterology Department II, Jinan people's Hospital Affiliated to Shandong First Medical University, 001 Xuehu Street, Changshao North Road, Laiwu District, Jinan City, 271100, ChinaCollege of Health, Binzhou Polytechnical College, No.919, Yellow River 12th Road, Binzhou, 256603, China; Corresponding author.This study presents a dual application approach for the environmentally friendly synthesis of gelatin hydrogel nanoparticles with potential applications in gastric cancer treatment, bisphenol A (BPA) sensing, and nursing. Gelatin hydrogel nanoparticles were synthesized using a green and freeze-drying method, avoiding the use of toxic chemicals and solvents. The nanoparticles showed excellent biocompatibility and promising potential for drug delivery system (DDS) in gastric cancer treatment. The controlled release of anticancer drugs from the gelatin nanoparticles was showed, highlighting their potential in targeted therapy. Additionally, the gelatin hydrogel nanoparticles were explored for BPA sensing. BPA is a widely used chemical known for its adverse effects on human health. The gelatin nanoparticles showed high selectivity and sensitivity towards BPA detection, making them suitable for environmental monitoring and health applications using scanning electron microscope (SEM). Also, in this study, an artificial neural network (ANN) was used to estimate the release of docetaxel (%) at 72 h, the release of paclitaxel (%) at 72 h, tensile strength with sample (wt%), and porosity (%) in broader ranges than the experimental samples. The environmentally friendly synthesis of gelatin hydrogel nanoparticles presented in this study offers a versatile platform with dual applications in gastric cancer treatment and sensing of harmful chemicals. The obtained results show the potential of these nanoparticles for innovative therapeutic and diagnostic strategies in healthcare and environmental monitoring. The study showed the development of sustainable and multifunctional nanomaterials for various biomedical applications. The modeling of the neural network predictions shows that increasing the sample (wt%) and porosity (%) leads to an increase in the release of docetaxel (%) at 72 h, the release of paclitaxel (%) at 72 h, and tensile strength. As porosity decreases, the release of docetaxel increases, and the release of paclitaxel and tensile strength also increase. Additionally, the prediction errors of the ANN in this study were evaluated using linear regression, showing acceptable error rates compared to the target results obtained from the experimental tests.http://www.sciencedirect.com/science/article/pii/S2405844024148657Gelatin hydrogel nanoparticlesGastric cancer treatmentBPA sensingNursing applicationsComputer Science |
| spellingShingle | Sun Qian Ruiyan Xu Environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment, bisphenol A sensing and nursing applications: Fabrication, characterization and ANN modeling Heliyon Gelatin hydrogel nanoparticles Gastric cancer treatment BPA sensing Nursing applications Computer Science |
| title | Environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment, bisphenol A sensing and nursing applications: Fabrication, characterization and ANN modeling |
| title_full | Environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment, bisphenol A sensing and nursing applications: Fabrication, characterization and ANN modeling |
| title_fullStr | Environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment, bisphenol A sensing and nursing applications: Fabrication, characterization and ANN modeling |
| title_full_unstemmed | Environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment, bisphenol A sensing and nursing applications: Fabrication, characterization and ANN modeling |
| title_short | Environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment, bisphenol A sensing and nursing applications: Fabrication, characterization and ANN modeling |
| title_sort | environmentally friendly synthesis of gelatin hydrogel nanoparticles for gastric cancer treatment bisphenol a sensing and nursing applications fabrication characterization and ann modeling |
| topic | Gelatin hydrogel nanoparticles Gastric cancer treatment BPA sensing Nursing applications Computer Science |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024148657 |
| work_keys_str_mv | AT sunqian environmentallyfriendlysynthesisofgelatinhydrogelnanoparticlesforgastriccancertreatmentbisphenolasensingandnursingapplicationsfabricationcharacterizationandannmodeling AT ruiyanxu environmentallyfriendlysynthesisofgelatinhydrogelnanoparticlesforgastriccancertreatmentbisphenolasensingandnursingapplicationsfabricationcharacterizationandannmodeling |