RNA N6‐Methyladenosine‐Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN‐γ Signaling in Gastric Cancer

RNA N6‐Methyladenosine‐Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN‐γ Signaling in Gastric Cancer

Abstract Immunotherapy holds potential as a treatment for gastric cancer (GC), though immune checkpoint inhibitor (ICI) resistance remains an obstacle. One resistance mechanism involves defects in interferon‐γ (IFN‐γ) signaling, in which IFN‐γ is linked to improved responsiveness to ICIs. Herein, th...

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Main Authors: Dongjun Jang, Chanwoong Hwa, Seoyeon Kim, Jaeik Oh, Seungjae Shin, Soo‐Jin Lee, Jiwon Kim, Sang Eun Lee, Yoojin Yang, Dohee Kim, Seoho Lee, Hae Rim Jung, Yumi Oh, Kyunggon Kim, Hye Seung Lee, Joon‐Yong An, Sung‐Yup Cho
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
cancer immunity
gastric cancer
interferon‐γ signaling
N6‐methyladenosine
YTHDF proteins
Online Access:https://doi.org/10.1002/advs.202410806
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