Recent advances in methylation modifications of microRNA
microRNAs (miRNAs) are short single-stranded non-coding RNAs between 21 and 25 nt in length in eukaryotic organisms, which control post-transcriptional gene expression. Through complementary base pairing, miRNAs generally bind to their target messenger RNAs and repress protein production by destabil...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-01-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223004841 |
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| author | Ning Su Xiaohang Yu Ming Duan Ning Shi |
| author_facet | Ning Su Xiaohang Yu Ming Duan Ning Shi |
| author_sort | Ning Su |
| collection | DOAJ |
| description | microRNAs (miRNAs) are short single-stranded non-coding RNAs between 21 and 25 nt in length in eukaryotic organisms, which control post-transcriptional gene expression. Through complementary base pairing, miRNAs generally bind to their target messenger RNAs and repress protein production by destabilizing the messenger RNA and translational silencing. They regulate almost all life activities, such as cell proliferation, differentiation, apoptosis, tumorigenesis, and host–pathogen interactions. Methylation modification is the most common RNA modification in eukaryotes. miRNA methylation exists in different types, mainly N6-methyladenosine, 5-methylcytosine, and 7-methylguanine, which can change the expression level and biological mode of action of miRNAs and improve the activity of regulating gene expression in a very fine-tuned way with flexibility. In this review, we will summarize the recent findings concerning methylation modifications of miRNA, focusing on their biogenesis and the potential role of miRNA fate and functions. |
| format | Article |
| id | doaj-art-09c45fb0ecbb4292b9cae0d58b878522 |
| institution | Kabale University |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-09c45fb0ecbb4292b9cae0d58b8785222024-11-13T04:29:48ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-01-01121101201Recent advances in methylation modifications of microRNANing Su0Xiaohang Yu1Ming Duan2Ning Shi3State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, ChinaState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, ChinaState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, ChinaCorresponding author. Tel.: +86 18946619322.; State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, ChinamicroRNAs (miRNAs) are short single-stranded non-coding RNAs between 21 and 25 nt in length in eukaryotic organisms, which control post-transcriptional gene expression. Through complementary base pairing, miRNAs generally bind to their target messenger RNAs and repress protein production by destabilizing the messenger RNA and translational silencing. They regulate almost all life activities, such as cell proliferation, differentiation, apoptosis, tumorigenesis, and host–pathogen interactions. Methylation modification is the most common RNA modification in eukaryotes. miRNA methylation exists in different types, mainly N6-methyladenosine, 5-methylcytosine, and 7-methylguanine, which can change the expression level and biological mode of action of miRNAs and improve the activity of regulating gene expression in a very fine-tuned way with flexibility. In this review, we will summarize the recent findings concerning methylation modifications of miRNA, focusing on their biogenesis and the potential role of miRNA fate and functions.http://www.sciencedirect.com/science/article/pii/S2352304223004841m5C modificationm6A modificationm7G modificationMethylation modificationmiRNA |
| spellingShingle | Ning Su Xiaohang Yu Ming Duan Ning Shi Recent advances in methylation modifications of microRNA Genes and Diseases m5C modification m6A modification m7G modification Methylation modification miRNA |
| title | Recent advances in methylation modifications of microRNA |
| title_full | Recent advances in methylation modifications of microRNA |
| title_fullStr | Recent advances in methylation modifications of microRNA |
| title_full_unstemmed | Recent advances in methylation modifications of microRNA |
| title_short | Recent advances in methylation modifications of microRNA |
| title_sort | recent advances in methylation modifications of microrna |
| topic | m5C modification m6A modification m7G modification Methylation modification miRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223004841 |
| work_keys_str_mv | AT ningsu recentadvancesinmethylationmodificationsofmicrorna AT xiaohangyu recentadvancesinmethylationmodificationsofmicrorna AT mingduan recentadvancesinmethylationmodificationsofmicrorna AT ningshi recentadvancesinmethylationmodificationsofmicrorna |