Loss of <i>Dnah5</i> Downregulates <i>Dync1h1</i> Expression, Causing Cortical Development Disorders and Congenital Hydrocephalus

Loss of <i>Dnah5</i> Downregulates <i>Dync1h1</i> Expression, Causing Cortical Development Disorders and Congenital Hydrocephalus

<i>Dnah5</i> is associated with primary ciliary dyskinesia in humans. <i>Dnah5</i>-knockout (<i>Dnah5</i>−/− mice develop acute hydrocephalus shortly after birth owing to impaired ciliary motility and cerebrospinal fluid (CSF) stagnation. In contrast to chronic ad...

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Bibliographic Details
Main Authors: Koichiro Sakamoto, Masakazu Miyajima, Madoka Nakajima, Ikuko Ogino, Kou Horikoshi, Ryo Miyahara, Kaito Kawamura, Kostadin Karagiozov, Chihiro Kamohara, Eri Nakamura, Nobuhiro Tada, Akihide Kondo
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
<i>Dnah5</i>
motile cilia
primary cilia
neurogenesis
cytoplasmic dynein
Online Access:https://www.mdpi.com/2073-4409/13/22/1882
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