A multi-organ, feto-maternal interface organ-on-chip, models pregnancy pathology and is a useful preclinical extracellular vesicle drug trial platform

A multi-organ, feto-maternal interface organ-on-chip, models pregnancy pathology and is a useful preclinical extracellular vesicle drug trial platform

Pregnant women and their fetuses are often excluded from clinical trials due to missing drug-related pre-clinical trial information at the human feto-maternal interface (FMi). The two interfaces-placenta/decidua and fetal membranes/decidua are gatekeepers of drug transport; however, testing their fu...

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Bibliographic Details
Main Authors: Melody Safarzadeh, Lauren S. Richardson, Ananth Kumar Kammala, Angela Mosebarger, Mohamed Bettayeb, Sungjin Kim, Po Yi Lam, Enkhtuya Radnaa, Arum Han, Ramkumar Menon
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Extracellular Vesicle
Subjects:
Microphysiological systems
Placenta
Fetal membrane
Interleukin-10
EVs
Preterm birth
Online Access:http://www.sciencedirect.com/science/article/pii/S2773041724000027
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