Optimizing microbiome reference databases with PacBio full-length 16S rRNA sequencing for enhanced taxonomic classification and biomarker discovery

Optimizing microbiome reference databases with PacBio full-length 16S rRNA sequencing for enhanced taxonomic classification and biomarker discovery

BackgroundThe study of the human microbiome is crucial for understanding disease mechanisms, identifying biomarkers, and guiding preventive measures. Advances in sequencing platforms, particularly 16S rRNA sequencing, have revolutionized microbiome research. Despite the benefits, large microbiome re...

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Bibliographic Details
Main Authors: Hyejung Han, Yoon Hee Choi, Si Yeong Kim, Jung Hwa Park, Jin Chung, Hee Sam Na
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Microbiology
Subjects:
oral microbiome
gut microbiome
PacBio
Illumina
next generation sequencing
reference database
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1485073/full
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