Oxidative stress-induced CDO1 glutathionylation regulates cysteine metabolism and sustains redox homeostasis under ionizing radiation

Oxidative stress-induced CDO1 glutathionylation regulates cysteine metabolism and sustains redox homeostasis under ionizing radiation

Oxidative stress serves as a fundamental mechanism contributing to ionizing radiation-induced damage, which has significant implications for tissue injury. Cysteine dioxygenase type 1 (CDO1) catalyzes the rate-limiting step for cysteine oxidation pathway, thereby playing a crucial role in regulating...

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Bibliographic Details
Main Authors: Yumin He, Dan Li, Hongping Ye, Jiang Zhu, Qianming Chen, Rui Liu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
CDO1
Glutathionylation
Oxidative stress
Radiation damage
Cysteine metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001697
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