Phase 1 clinical trial of Hantaan and Puumala virus DNA vaccines delivered by needle-free injection

Phase 1 clinical trial of Hantaan and Puumala virus DNA vaccines delivered by needle-free injection

Abstract Hantaan virus (HTNV) and Puumala virus (PUUV) are pathogenic zoonoses found in Asia and Europe, respectively. We conducted a randomized Phase 1 clinical trial of individual HTNV and PUUV DNA vaccines targeting the envelope glycoproteins (GnGc), as well as a combined HTNV/PUUV DNA vaccine de...

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Main Authors: Jay W. Hooper, Steven A. Kwilas, Matthew Josleyn, Sarah Norris, Jack N. Hutter, Melinda Hamer, Jeffrey Livezey, Kristopher Paolino, Patrick Twomey, Michael Koren, Paul Keiser, James E. Moon, Ugo Nwaeze, Jason Koontz, Carmen Ledesma-Feliciano, Nathalie Landry, Trevor Wellington
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-00998-7
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https://doi.org/10.1038/s41541-024-00998-7

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