Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics

Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics

Summary: Epigenetic gestational age acceleration has been implicated in obstetric syndromes including preeclampsia, yet robust conclusions require accurate and unbiased epigenetic age models. Herein, we curated 1,842 public placental methylomes and organized a DREAM challenge to develop models of ge...

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Main Authors: Gaurav Bhatti, Herdiantri Sufriyana, Roberto Romero, Tushar Patel, Fasil Tekola-Ayele, Ibrahim Alsaggaf, Nardhy Gomez-Lopez, Emily C.Y. Su, Bogdan Done, Steve Hoffmann, Alena van Bömmel, Cen Wan, Jake Albrecht, Charles Novak, Tinnakorn Chaiworapongsa, Marina Sirota, Nima Aghaeepour, Gustavo Stolovitzky, David R. Bryant, Adi L. Tarca
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Epigenetics
Pregnancy
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014427
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