CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer
Introduction: Various strategies, starting with surgery, systemic radiation therapy with cytotoxic chemotherapy, and immunotherapy, have been carried out to address mortality from lung cancer. None of these therapies has showed remarkably successful treatments for lung cancer. Developing technology...
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2024-12-01
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| Series: | Research Results in Pharmacology |
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| Online Access: | https://rrpharmacology.ru/index.php/journal/article/view/522 |
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| _version_ | 1841554605051215872 |
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| author | Angeline Felisca Tanujaya Dhea Anggraini Ahmad Dzulfikri Nurhan |
| author_facet | Angeline Felisca Tanujaya Dhea Anggraini Ahmad Dzulfikri Nurhan |
| author_sort | Angeline Felisca Tanujaya |
| collection | DOAJ |
| description | Introduction: Various strategies, starting with surgery, systemic radiation therapy with cytotoxic chemotherapy, and immunotherapy, have been carried out to address mortality from lung cancer. None of these therapies has showed remarkably successful treatments for lung cancer. Developing technology leads to innovation of cancer-targeted therapy as an ideal strategy. Chimeric antigen receptor T cells (CAR-T cells) are one of the novel immunotherapy approaches in genetic engineering. CAR-T therapy has showed promising results as the cancer-targeted therapy.
Methods: This review identifies relevant research by the keywords “Lung Cancer”, “CAR-T for Lung Cancer”, “CAR-T for solid tumor”, “CAR-T for SCLC” or “CAR-T for NSCLC”. The articles are extracted from Pubmed, Web of Science, Scopus, Science Direct, and Google Scholar. Data are shown based on discussions of the modification receptor, co-stimulator, and CAR-T cells.
Results: CAR-T acts to overcome lung cancer by targeting several receptors, such as mesothelin and c-Met. Several generations have also evolved to more specific and effective therapy. CAR-T modifications like BBIR, SUPRA CAR, and UIR have also been developed to minimize side effects.
Conclusion: CAR-T developments are not limited to CAR modification, but include its components and structure. |
| format | Article |
| id | doaj-art-098d35e4d54c4360876c370d2a086a1c |
| institution | Kabale University |
| issn | 2658-381X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj-art-098d35e4d54c4360876c370d2a086a1c2025-01-08T13:10:23ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2024-12-01104778610.18413/rrpharmacology.10.522CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancerAngeline Felisca Tanujaya0https://orcid.org/0009-0009-8151-0208Dhea Anggraini1https://orcid.org/0009-0004-8201-9318Ahmad Dzulfikri Nurhan2Faculty of Pharmacy, Universitas Airlangga, IndonesiaFaculty of Pharmacy, Universitas Airlangga, IndonesiaDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, IndonesiaIntroduction: Various strategies, starting with surgery, systemic radiation therapy with cytotoxic chemotherapy, and immunotherapy, have been carried out to address mortality from lung cancer. None of these therapies has showed remarkably successful treatments for lung cancer. Developing technology leads to innovation of cancer-targeted therapy as an ideal strategy. Chimeric antigen receptor T cells (CAR-T cells) are one of the novel immunotherapy approaches in genetic engineering. CAR-T therapy has showed promising results as the cancer-targeted therapy. Methods: This review identifies relevant research by the keywords “Lung Cancer”, “CAR-T for Lung Cancer”, “CAR-T for solid tumor”, “CAR-T for SCLC” or “CAR-T for NSCLC”. The articles are extracted from Pubmed, Web of Science, Scopus, Science Direct, and Google Scholar. Data are shown based on discussions of the modification receptor, co-stimulator, and CAR-T cells. Results: CAR-T acts to overcome lung cancer by targeting several receptors, such as mesothelin and c-Met. Several generations have also evolved to more specific and effective therapy. CAR-T modifications like BBIR, SUPRA CAR, and UIR have also been developed to minimize side effects. Conclusion: CAR-T developments are not limited to CAR modification, but include its components and structure.https://rrpharmacology.ru/index.php/journal/article/view/522cancerlung cancersolid tumorchimeric antigen receptorcar-t modificationgenetic engineering |
| spellingShingle | Angeline Felisca Tanujaya Dhea Anggraini Ahmad Dzulfikri Nurhan CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer Research Results in Pharmacology cancer lung cancer solid tumor chimeric antigen receptor car-t modification genetic engineering |
| title | CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer |
| title_full | CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer |
| title_fullStr | CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer |
| title_full_unstemmed | CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer |
| title_short | CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer |
| title_sort | car t cells prospective genetic engineering approach to orchestrate solid tumor in lung cancer |
| topic | cancer lung cancer solid tumor chimeric antigen receptor car-t modification genetic engineering |
| url | https://rrpharmacology.ru/index.php/journal/article/view/522 |
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