Immune Privilege and Eye-Derived T-Regulatory Cells
Certain cellular components of the eye, such as neural retina, are unable to regenerate and replicate after destructive inflammation. Ocular immune privilege provides the eye with immune protection against intraocular inflammation in order to minimize the risk to vision integrity. The eye and immune...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1679197 |
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| author | Hiroshi Keino Shintaro Horie Sunao Sugita |
| author_facet | Hiroshi Keino Shintaro Horie Sunao Sugita |
| author_sort | Hiroshi Keino |
| collection | DOAJ |
| description | Certain cellular components of the eye, such as neural retina, are unable to regenerate and replicate after destructive inflammation. Ocular immune privilege provides the eye with immune protection against intraocular inflammation in order to minimize the risk to vision integrity. The eye and immune system use strategies to maintain the ocular immune privilege by regulating the innate and adaptive immune response, which includes immunological ignorance, peripheral tolerance to eye-derived antigens, and intraocular immunosuppressive microenvironment. In this review, we summarize current knowledge regarding the molecular mechanism responsible for the development and maintenance of ocular immune privilege via regulatory T cells (Tregs), which are generated by the anterior chamber-associated immune deviation (ACAID), and ocular resident cells including corneal endothelial (CE) cells, ocular pigment epithelial (PE) cells, and aqueous humor. Furthermore, we examined the therapeutic potential of Tregs generated by RPE cells that express transforming growth factor beta (TGF-β), cytotoxic T lymphocyte-associated antigen-2 alpha (CTLA-2α), and retinoic acid for autoimmune uveoretinitis and evaluated a new strategy using human RPE-induced Tregs for clinical application in inflammatory ocular disease. We believe that a better understanding of the ocular immune privilege associated with Tregs might offer a new approach with regard to therapeutic interventions for ocular autoimmunity. |
| format | Article |
| id | doaj-art-09820d76f7f84248bb4e79656683d62c |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-09820d76f7f84248bb4e79656683d62c2025-02-03T05:47:14ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/16791971679197Immune Privilege and Eye-Derived T-Regulatory CellsHiroshi Keino0Shintaro Horie1Sunao Sugita2Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, JapanDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, JapanLaboratory for Retinal Regeneration, Center for Developmental Biology, Riken, Kobe, JapanCertain cellular components of the eye, such as neural retina, are unable to regenerate and replicate after destructive inflammation. Ocular immune privilege provides the eye with immune protection against intraocular inflammation in order to minimize the risk to vision integrity. The eye and immune system use strategies to maintain the ocular immune privilege by regulating the innate and adaptive immune response, which includes immunological ignorance, peripheral tolerance to eye-derived antigens, and intraocular immunosuppressive microenvironment. In this review, we summarize current knowledge regarding the molecular mechanism responsible for the development and maintenance of ocular immune privilege via regulatory T cells (Tregs), which are generated by the anterior chamber-associated immune deviation (ACAID), and ocular resident cells including corneal endothelial (CE) cells, ocular pigment epithelial (PE) cells, and aqueous humor. Furthermore, we examined the therapeutic potential of Tregs generated by RPE cells that express transforming growth factor beta (TGF-β), cytotoxic T lymphocyte-associated antigen-2 alpha (CTLA-2α), and retinoic acid for autoimmune uveoretinitis and evaluated a new strategy using human RPE-induced Tregs for clinical application in inflammatory ocular disease. We believe that a better understanding of the ocular immune privilege associated with Tregs might offer a new approach with regard to therapeutic interventions for ocular autoimmunity.http://dx.doi.org/10.1155/2018/1679197 |
| spellingShingle | Hiroshi Keino Shintaro Horie Sunao Sugita Immune Privilege and Eye-Derived T-Regulatory Cells Journal of Immunology Research |
| title | Immune Privilege and Eye-Derived T-Regulatory Cells |
| title_full | Immune Privilege and Eye-Derived T-Regulatory Cells |
| title_fullStr | Immune Privilege and Eye-Derived T-Regulatory Cells |
| title_full_unstemmed | Immune Privilege and Eye-Derived T-Regulatory Cells |
| title_short | Immune Privilege and Eye-Derived T-Regulatory Cells |
| title_sort | immune privilege and eye derived t regulatory cells |
| url | http://dx.doi.org/10.1155/2018/1679197 |
| work_keys_str_mv | AT hiroshikeino immuneprivilegeandeyederivedtregulatorycells AT shintarohorie immuneprivilegeandeyederivedtregulatorycells AT sunaosugita immuneprivilegeandeyederivedtregulatorycells |