The prognosis for delayed immune recovery in HIV-infected children might be associated with pre-cART CD4+ T cell count irrespective of co-infection with tuberculosis
Abstract Background Immune reconstitution following the initiation of combination antiretroviral therapy (cART) significantly impacts the prognosis of individuals infected with human immunodeficiency virus (HIV). Our previous studies have indicated that the baseline CD4+ T cells count and percentage...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-024-07032-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544945306959872 |
|---|---|
| author | Funsho J. Ogunshola Ruhul A. Khan Musie Ghebremichael |
| author_facet | Funsho J. Ogunshola Ruhul A. Khan Musie Ghebremichael |
| author_sort | Funsho J. Ogunshola |
| collection | DOAJ |
| description | Abstract Background Immune reconstitution following the initiation of combination antiretroviral therapy (cART) significantly impacts the prognosis of individuals infected with human immunodeficiency virus (HIV). Our previous studies have indicated that the baseline CD4+ T cells count and percentage before cART initiation are predictors of immune recovery in TB-negative children infected with HIV, with TB co-infection potentially causing a delay in immune recovery. However, it remains unclear whether these predictors consistently impact immune reconstitution during long-term intensive cART treatment in TB-negative/positive children infected with HIV. Results We confirmed that the baseline CD4+ T cell count is a significant predictor of immune recovery following long-term intensive cART treatment among children aged 0 to 13 years. Children with lower CD4+ T cell count prior cART initiation did not show substantial immunological recovery during the follow-up period. Interestingly, children who were co-infected with TB and had higher baseline CD4+ T cell count eventually achieved good immunological recovery comparable to the TB-negative HIV-infected children. Hence, the baseline CD4+ T cell count at the onset of treatment serves as a reliable predictor of immunological reconstitution in HIV-infected children with or without TB co-infection. Taken together, this follow-up study validates our previous findings and further establishes that initiating cART early alongside early HIV testing can help prevent the diminished CD4+ T cell count associated with inadequate immunological reconstitution. |
| format | Article |
| id | doaj-art-095fc1b568524b9c9a3254360f7db9fe |
| institution | Kabale University |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-095fc1b568524b9c9a3254360f7db9fe2025-01-12T12:06:50ZengBMCBMC Research Notes1756-05002025-01-011811810.1186/s13104-024-07032-yThe prognosis for delayed immune recovery in HIV-infected children might be associated with pre-cART CD4+ T cell count irrespective of co-infection with tuberculosisFunsho J. Ogunshola0Ruhul A. Khan1Musie Ghebremichael2Ragon Institute of MGH, MIT, and HarvardDepartment of Mathematics, University of ArizonaRagon Institute of MGH, MIT, and HarvardAbstract Background Immune reconstitution following the initiation of combination antiretroviral therapy (cART) significantly impacts the prognosis of individuals infected with human immunodeficiency virus (HIV). Our previous studies have indicated that the baseline CD4+ T cells count and percentage before cART initiation are predictors of immune recovery in TB-negative children infected with HIV, with TB co-infection potentially causing a delay in immune recovery. However, it remains unclear whether these predictors consistently impact immune reconstitution during long-term intensive cART treatment in TB-negative/positive children infected with HIV. Results We confirmed that the baseline CD4+ T cell count is a significant predictor of immune recovery following long-term intensive cART treatment among children aged 0 to 13 years. Children with lower CD4+ T cell count prior cART initiation did not show substantial immunological recovery during the follow-up period. Interestingly, children who were co-infected with TB and had higher baseline CD4+ T cell count eventually achieved good immunological recovery comparable to the TB-negative HIV-infected children. Hence, the baseline CD4+ T cell count at the onset of treatment serves as a reliable predictor of immunological reconstitution in HIV-infected children with or without TB co-infection. Taken together, this follow-up study validates our previous findings and further establishes that initiating cART early alongside early HIV testing can help prevent the diminished CD4+ T cell count associated with inadequate immunological reconstitution.https://doi.org/10.1186/s13104-024-07032-yHIVTBImmune recoveryCD4+ T cell countCART initiationPiecewise linear and mixed-effects models |
| spellingShingle | Funsho J. Ogunshola Ruhul A. Khan Musie Ghebremichael The prognosis for delayed immune recovery in HIV-infected children might be associated with pre-cART CD4+ T cell count irrespective of co-infection with tuberculosis BMC Research Notes HIV TB Immune recovery CD4+ T cell count CART initiation Piecewise linear and mixed-effects models |
| title | The prognosis for delayed immune recovery in HIV-infected children might be associated with pre-cART CD4+ T cell count irrespective of co-infection with tuberculosis |
| title_full | The prognosis for delayed immune recovery in HIV-infected children might be associated with pre-cART CD4+ T cell count irrespective of co-infection with tuberculosis |
| title_fullStr | The prognosis for delayed immune recovery in HIV-infected children might be associated with pre-cART CD4+ T cell count irrespective of co-infection with tuberculosis |
| title_full_unstemmed | The prognosis for delayed immune recovery in HIV-infected children might be associated with pre-cART CD4+ T cell count irrespective of co-infection with tuberculosis |
| title_short | The prognosis for delayed immune recovery in HIV-infected children might be associated with pre-cART CD4+ T cell count irrespective of co-infection with tuberculosis |
| title_sort | prognosis for delayed immune recovery in hiv infected children might be associated with pre cart cd4 t cell count irrespective of co infection with tuberculosis |
| topic | HIV TB Immune recovery CD4+ T cell count CART initiation Piecewise linear and mixed-effects models |
| url | https://doi.org/10.1186/s13104-024-07032-y |
| work_keys_str_mv | AT funshojogunshola theprognosisfordelayedimmunerecoveryinhivinfectedchildrenmightbeassociatedwithprecartcd4tcellcountirrespectiveofcoinfectionwithtuberculosis AT ruhulakhan theprognosisfordelayedimmunerecoveryinhivinfectedchildrenmightbeassociatedwithprecartcd4tcellcountirrespectiveofcoinfectionwithtuberculosis AT musieghebremichael theprognosisfordelayedimmunerecoveryinhivinfectedchildrenmightbeassociatedwithprecartcd4tcellcountirrespectiveofcoinfectionwithtuberculosis AT funshojogunshola prognosisfordelayedimmunerecoveryinhivinfectedchildrenmightbeassociatedwithprecartcd4tcellcountirrespectiveofcoinfectionwithtuberculosis AT ruhulakhan prognosisfordelayedimmunerecoveryinhivinfectedchildrenmightbeassociatedwithprecartcd4tcellcountirrespectiveofcoinfectionwithtuberculosis AT musieghebremichael prognosisfordelayedimmunerecoveryinhivinfectedchildrenmightbeassociatedwithprecartcd4tcellcountirrespectiveofcoinfectionwithtuberculosis |