Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism
A 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar and blood pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, and adrenocorticotropic hormone inhibition. Cortisol levels remained unrespons...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1383987/full |
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| author | Yuan Zhong Tao Zhang Fan Li Yong Chen Liwei Tong Chenxi Xia Dong Wei |
| author_facet | Yuan Zhong Tao Zhang Fan Li Yong Chen Liwei Tong Chenxi Xia Dong Wei |
| author_sort | Yuan Zhong |
| collection | DOAJ |
| description | A 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar and blood pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, and adrenocorticotropic hormone inhibition. Cortisol levels remained unresponsive to both low-dose and high-dose dexamethasone tests, leading to a diagnosis of primary bilateral macronodular adrenal hyperplasia. Concurrently, elevated blood calcium and parathyroid hormone levels, along with 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) imaging revealing increased 99mTc-MIBI uptake in the right inferior parathyroid gland, suggest the consideration of primary hyperparathyroidism. This case is presented in light of the uncommon clinical coexistence of primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism. |
| format | Article |
| id | doaj-art-09544ff9d9074f37a88fdaf71eeb4662 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-09544ff9d9074f37a88fdaf71eeb46622024-12-16T04:17:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.13839871383987Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidismYuan Zhong0Tao Zhang1Fan Li2Yong Chen3Liwei Tong4Chenxi Xia5Dong Wei6Department of Endocrinology, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Medical Imaging, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Pathology, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Urology, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Endocrinology, Zigong Fourth People’s Hospital, Zigong, ChinaDepartment of Endocrinology, Chengdu Second People’s Hospital, Chengdu, ChinaDepartment of Endocrinology, Chengdu Second People’s Hospital, Chengdu, ChinaA 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar and blood pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, and adrenocorticotropic hormone inhibition. Cortisol levels remained unresponsive to both low-dose and high-dose dexamethasone tests, leading to a diagnosis of primary bilateral macronodular adrenal hyperplasia. Concurrently, elevated blood calcium and parathyroid hormone levels, along with 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) imaging revealing increased 99mTc-MIBI uptake in the right inferior parathyroid gland, suggest the consideration of primary hyperparathyroidism. This case is presented in light of the uncommon clinical coexistence of primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism.https://www.frontiersin.org/articles/10.3389/fendo.2024.1383987/fullprimary bilateral macronodular adrenal hyperplasiaprimary hyperparathyroidismtype 2 diabetes mellitusCushing’s syndromemultiple endocrine neoplasia type 1 (MEN 1) |
| spellingShingle | Yuan Zhong Tao Zhang Fan Li Yong Chen Liwei Tong Chenxi Xia Dong Wei Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism Frontiers in Endocrinology primary bilateral macronodular adrenal hyperplasia primary hyperparathyroidism type 2 diabetes mellitus Cushing’s syndrome multiple endocrine neoplasia type 1 (MEN 1) |
| title | Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism |
| title_full | Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism |
| title_fullStr | Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism |
| title_full_unstemmed | Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism |
| title_short | Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism |
| title_sort | case report a 51 year old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism |
| topic | primary bilateral macronodular adrenal hyperplasia primary hyperparathyroidism type 2 diabetes mellitus Cushing’s syndrome multiple endocrine neoplasia type 1 (MEN 1) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1383987/full |
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