Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom Studies
A recent method based on positron emission was reported for tracking moving point sources using the Inveon PET system. However, the effect of scanner background noise was not further explored. Here, we evaluate tracking with the Genisys4, a bismuth germanate-based PET system, which has no significan...
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SAGE Publishing
2016-05-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012116646489 |
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| author | Yu Ouyang PhD Tae Jin Kim PhD Guillem Pratx PhD |
| author_facet | Yu Ouyang PhD Tae Jin Kim PhD Guillem Pratx PhD |
| author_sort | Yu Ouyang PhD |
| collection | DOAJ |
| description | A recent method based on positron emission was reported for tracking moving point sources using the Inveon PET system. However, the effect of scanner background noise was not further explored. Here, we evaluate tracking with the Genisys4, a bismuth germanate-based PET system, which has no significant intrinsic background and may be better suited to tracking lower and/or faster activity sources. Position-dependent sensitivity of the Genisys4 was simulated in Geant4 Application for Tomographic Emission (GATE) using a static 18 F point source. Trajectories of helically moving point sources with varying activity and rotation speed were reconstructed from list-mode data as described previously. Simulations showed that the Inveon’s ability to track sources within 2 mm of localization error is limited to objects with a velocity-to-activity ratio < 0.13 mm/decay, compared to < 0.29 mm/decay for the Genisys4. Tracking with the Genisys4 was then validated using a physical phantom of helically moving [ 18 F] fluorodeoxyglucose-in-oil droplets (< 0.24 mm diameter, 139-296 Bq), yielding < 1 mm localization error under the tested conditions, with good agreement between simulated sensitivity and measured activity (Pearson correlation R = .64, P << .05 in a representative example). We have investigated the tracking performance with the Genisys4, and results suggest the feasibility of tracking low activity, point source-like objects with this system. |
| format | Article |
| id | doaj-art-0924e37cbe3e40f1876b30334a622665 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | SAGE Publishing |
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| series | Molecular Imaging |
| spelling | doaj-art-0924e37cbe3e40f1876b30334a6226652025-01-03T00:11:13ZengSAGE PublishingMolecular Imaging1536-01212016-05-011510.1177/153601211664648910.1177_1536012116646489Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom StudiesYu Ouyang PhD0Tae Jin Kim PhD1Guillem Pratx PhD2 Radiation Biophysics Laboratory, Department of Radiation Oncology, Stanford University, Palo Alto, CA, USA Radiation Biophysics Laboratory, Department of Radiation Oncology, Stanford University, Palo Alto, CA, USA Radiation Biophysics Laboratory, Department of Radiation Oncology, Stanford University, Palo Alto, CA, USAA recent method based on positron emission was reported for tracking moving point sources using the Inveon PET system. However, the effect of scanner background noise was not further explored. Here, we evaluate tracking with the Genisys4, a bismuth germanate-based PET system, which has no significant intrinsic background and may be better suited to tracking lower and/or faster activity sources. Position-dependent sensitivity of the Genisys4 was simulated in Geant4 Application for Tomographic Emission (GATE) using a static 18 F point source. Trajectories of helically moving point sources with varying activity and rotation speed were reconstructed from list-mode data as described previously. Simulations showed that the Inveon’s ability to track sources within 2 mm of localization error is limited to objects with a velocity-to-activity ratio < 0.13 mm/decay, compared to < 0.29 mm/decay for the Genisys4. Tracking with the Genisys4 was then validated using a physical phantom of helically moving [ 18 F] fluorodeoxyglucose-in-oil droplets (< 0.24 mm diameter, 139-296 Bq), yielding < 1 mm localization error under the tested conditions, with good agreement between simulated sensitivity and measured activity (Pearson correlation R = .64, P << .05 in a representative example). We have investigated the tracking performance with the Genisys4, and results suggest the feasibility of tracking low activity, point source-like objects with this system.https://doi.org/10.1177/1536012116646489 |
| spellingShingle | Yu Ouyang PhD Tae Jin Kim PhD Guillem Pratx PhD Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom Studies Molecular Imaging |
| title | Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom Studies |
| title_full | Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom Studies |
| title_fullStr | Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom Studies |
| title_full_unstemmed | Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom Studies |
| title_short | Evaluation of a BGO-Based PET System for Single-Cell Tracking Performance by Simulation and Phantom Studies |
| title_sort | evaluation of a bgo based pet system for single cell tracking performance by simulation and phantom studies |
| url | https://doi.org/10.1177/1536012116646489 |
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