Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study
Abstract Background Investigate the safety and efficacy of preoperative atomization inhalation of indocyanine green (ICG) solution in precise lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration. Methods A multicenter 1:1 matched case-control study was adopted, to compare t...
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BMC
2024-11-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-024-03024-5 |
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| author | Ye Yin Guofeng Zhang Wei LI Didi Zhuansun Xiaofeng Xiong Yanan Li Yin He Wenjing Wang Tianqi Zhu Jiexiong Feng |
| author_facet | Ye Yin Guofeng Zhang Wei LI Didi Zhuansun Xiaofeng Xiong Yanan Li Yin He Wenjing Wang Tianqi Zhu Jiexiong Feng |
| author_sort | Ye Yin |
| collection | DOAJ |
| description | Abstract Background Investigate the safety and efficacy of preoperative atomization inhalation of indocyanine green (ICG) solution in precise lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration. Methods A multicenter 1:1 matched case-control study was adopted, to compare the safety and efficacy of the ICG group (preoperative atomization inhalation of 0.5 mg/kg ICG solution) with traditional group (no preoperative atomization inhalation of ICG solution). The baseline, intraoperative, and postoperative recovery conditions of the two groups were observed. Outpatient follow-up visits were conducted 3 to 6 months after surgery, including lung CT scans and pulmonary ventilation function tests. Results 134 patients were included in the study. The ICG group included 67 patients, and the traditional surgery group included 67 patients matched at a ratio of 1:1 according to age and lesion location. There were no reports of deaths or adverse reactions. The postoperative chest drainage tube indwelling time [(53.19 ± 8.15) hours vs. (73.25 ± 15.51) hours, P < 0.001] and postoperative hospital stay [(4.81 ± 1.84) days vs. (6.72 ± 1.31) days, P < 0.001] were shorter in the ICG group than in the traditional group. More importantly, the postoperative pulmonary function in the ICG group was better than that in the traditional group. No residual lesions were found in the postoperative CT examination of both groups. Conclusions The innovative application of atomization inhalation of ICG provides the possibility for precise localization and lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration. This maximizes the preservation of normal lung parenchyma, better improves postoperative pulmonary function, and shortens postoperative recovery time. |
| format | Article |
| id | doaj-art-09077e47efa6471bae9ba58726b7aaad |
| institution | Kabale University |
| issn | 1465-993X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj-art-09077e47efa6471bae9ba58726b7aaad2024-11-10T12:40:06ZengBMCRespiratory Research1465-993X2024-11-012511710.1186/s12931-024-03024-5Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter studyYe Yin0Guofeng Zhang1Wei LI2Didi Zhuansun3Xiaofeng Xiong4Yanan Li5Yin He6Wenjing Wang7Tianqi Zhu8Jiexiong Feng9Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pediatric Surgery, First Hospital Affiliated to Zhengzhou UniversityDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pediatric Surgery, First Hospital Affiliated to Zhengzhou UniversityDepartment of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Investigate the safety and efficacy of preoperative atomization inhalation of indocyanine green (ICG) solution in precise lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration. Methods A multicenter 1:1 matched case-control study was adopted, to compare the safety and efficacy of the ICG group (preoperative atomization inhalation of 0.5 mg/kg ICG solution) with traditional group (no preoperative atomization inhalation of ICG solution). The baseline, intraoperative, and postoperative recovery conditions of the two groups were observed. Outpatient follow-up visits were conducted 3 to 6 months after surgery, including lung CT scans and pulmonary ventilation function tests. Results 134 patients were included in the study. The ICG group included 67 patients, and the traditional surgery group included 67 patients matched at a ratio of 1:1 according to age and lesion location. There were no reports of deaths or adverse reactions. The postoperative chest drainage tube indwelling time [(53.19 ± 8.15) hours vs. (73.25 ± 15.51) hours, P < 0.001] and postoperative hospital stay [(4.81 ± 1.84) days vs. (6.72 ± 1.31) days, P < 0.001] were shorter in the ICG group than in the traditional group. More importantly, the postoperative pulmonary function in the ICG group was better than that in the traditional group. No residual lesions were found in the postoperative CT examination of both groups. Conclusions The innovative application of atomization inhalation of ICG provides the possibility for precise localization and lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration. This maximizes the preservation of normal lung parenchyma, better improves postoperative pulmonary function, and shortens postoperative recovery time.https://doi.org/10.1186/s12931-024-03024-5Indocyanine greenAtomization inhalationIntralobar pulmonary sequestrationPulmonary function |
| spellingShingle | Ye Yin Guofeng Zhang Wei LI Didi Zhuansun Xiaofeng Xiong Yanan Li Yin He Wenjing Wang Tianqi Zhu Jiexiong Feng Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study Respiratory Research Indocyanine green Atomization inhalation Intralobar pulmonary sequestration Pulmonary function |
| title | Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study |
| title_full | Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study |
| title_fullStr | Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study |
| title_full_unstemmed | Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study |
| title_short | Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study |
| title_sort | atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration a multicenter study |
| topic | Indocyanine green Atomization inhalation Intralobar pulmonary sequestration Pulmonary function |
| url | https://doi.org/10.1186/s12931-024-03024-5 |
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