A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal Neurogenesis
Immune regulation of the brain is generally studied in the context of injury or disease. Less is known about how the immune system regulates the brain during normal brain function. Recent work has redefined the field of neuroimmunology and, as long as their recruitment and activation are well regula...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1681590 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849305309348102144 |
|---|---|
| author | Odette Leiter Gerd Kempermann Tara L. Walker |
| author_facet | Odette Leiter Gerd Kempermann Tara L. Walker |
| author_sort | Odette Leiter |
| collection | DOAJ |
| description | Immune regulation of the brain is generally studied in the context of injury or disease. Less is known about how the immune system regulates the brain during normal brain function. Recent work has redefined the field of neuroimmunology and, as long as their recruitment and activation are well regulated, immune cells are now known to have protective properties within the central nervous system in maintaining brain health. Adult neurogenesis, the process of new neuron generation in the adult brain, is highly plastic and regulated by diverse extrinsic and intrinsic cues. Emerging research has shown that immune cells and their secreted factors can influence adult neurogenesis, both under baseline conditions and during conditions known to change neurogenesis levels, such as aging and learning in an enriched environment. This review will discuss how, under nonpathological conditions, the immune system can interact with the neural stem cells to regulate adult neurogenesis with particular focus on the hippocampus—a region crucial for learning and memory. |
| format | Article |
| id | doaj-art-0905724f8aee40339c7e917e34b8ce4c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0905724f8aee40339c7e917e34b8ce4c2025-08-20T03:55:29ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/16815901681590A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal NeurogenesisOdette Leiter0Gerd Kempermann1Tara L. Walker2Center for Regenerative Therapies Dresden (CRTD), Technische Universitaet Dresden, 01307 Dresden, GermanyCenter for Regenerative Therapies Dresden (CRTD), Technische Universitaet Dresden, 01307 Dresden, GermanyCenter for Regenerative Therapies Dresden (CRTD), Technische Universitaet Dresden, 01307 Dresden, GermanyImmune regulation of the brain is generally studied in the context of injury or disease. Less is known about how the immune system regulates the brain during normal brain function. Recent work has redefined the field of neuroimmunology and, as long as their recruitment and activation are well regulated, immune cells are now known to have protective properties within the central nervous system in maintaining brain health. Adult neurogenesis, the process of new neuron generation in the adult brain, is highly plastic and regulated by diverse extrinsic and intrinsic cues. Emerging research has shown that immune cells and their secreted factors can influence adult neurogenesis, both under baseline conditions and during conditions known to change neurogenesis levels, such as aging and learning in an enriched environment. This review will discuss how, under nonpathological conditions, the immune system can interact with the neural stem cells to regulate adult neurogenesis with particular focus on the hippocampus—a region crucial for learning and memory.http://dx.doi.org/10.1155/2016/1681590 |
| spellingShingle | Odette Leiter Gerd Kempermann Tara L. Walker A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal Neurogenesis Stem Cells International |
| title | A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal Neurogenesis |
| title_full | A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal Neurogenesis |
| title_fullStr | A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal Neurogenesis |
| title_full_unstemmed | A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal Neurogenesis |
| title_short | A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal Neurogenesis |
| title_sort | common language how neuroimmunological cross talk regulates adult hippocampal neurogenesis |
| url | http://dx.doi.org/10.1155/2016/1681590 |
| work_keys_str_mv | AT odetteleiter acommonlanguagehowneuroimmunologicalcrosstalkregulatesadulthippocampalneurogenesis AT gerdkempermann acommonlanguagehowneuroimmunologicalcrosstalkregulatesadulthippocampalneurogenesis AT taralwalker acommonlanguagehowneuroimmunologicalcrosstalkregulatesadulthippocampalneurogenesis AT odetteleiter commonlanguagehowneuroimmunologicalcrosstalkregulatesadulthippocampalneurogenesis AT gerdkempermann commonlanguagehowneuroimmunologicalcrosstalkregulatesadulthippocampalneurogenesis AT taralwalker commonlanguagehowneuroimmunologicalcrosstalkregulatesadulthippocampalneurogenesis |