Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study
Background. Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered. Design and Methods. We conducted a prospective, longitudinal, and controlled study in 23 women with a diagnosis of a compl...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/191247 |
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| author | René Rodríguez-Gutiérrez Jesús Zacarías Villarreal-Pérez Felipe Arturo Morales-Martinez René Rodríguez-Guajardo Gloria González-Saldivar Leonardo G. Mancillas-Adame Neri Alejandro Alvarez-Villalobos Fernando Javier Lavalle-Gonzalez José Gerardo González-González |
| author_facet | René Rodríguez-Gutiérrez Jesús Zacarías Villarreal-Pérez Felipe Arturo Morales-Martinez René Rodríguez-Guajardo Gloria González-Saldivar Leonardo G. Mancillas-Adame Neri Alejandro Alvarez-Villalobos Fernando Javier Lavalle-Gonzalez José Gerardo González-González |
| author_sort | René Rodríguez-Gutiérrez |
| collection | DOAJ |
| description | Background. Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered. Design and Methods. We conducted a prospective, longitudinal, and controlled study in 23 women with a diagnosis of a complete hydatidiform mole (HM). Results. All participants completed the study. Before HM evacuation mean hCG was markedly higher in the cases than in the control group (P≤0.001). Free testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) were found to be higher in the cases (2.78 ± 1.24 pg/mL and 231.50 ± 127.20 μ/dL) when compared to the control group (1.50 ± 0.75 pg/mL and 133.59 ± 60.69 μ/dL) (P=0.0001 and 0.001), respectively. There was a strong correlation between hCG and free T/total T/DHEA-S concentrations (r=0.78; P≤0.001, r=0.74; P≤0.001, and r=0.71; P≤0.001), respectively. In the cases group 48 hours after HM evacuation, hCG levels were found to be significantly lower when compared to initial levels (P=0.001) and free T and DHEA-S declined significantly (P=0.0002 and 0.009). Conclusion. Before uterus evacuation, hCG, free T, and DHEA-S levels were significantly higher when compared with controls finding a strong correlation between hCG and free T/DHEA-S levels. Forty-eight hours after HM treatment hCG levels declined and the difference was lost. A novel finding of our study is that in cases, besides free T, DHEA-S was also found to be significantly higher and both the ovaries and adrenal glands appear to be the sites of this androgen overproduction. |
| format | Article |
| id | doaj-art-08fbf9c2c4a34b09b99c5d05fbbb68fe |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-08fbf9c2c4a34b09b99c5d05fbbb68fe2025-08-20T03:55:33ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/191247191247Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled StudyRené Rodríguez-Gutiérrez0Jesús Zacarías Villarreal-Pérez1Felipe Arturo Morales-Martinez2René Rodríguez-Guajardo3Gloria González-Saldivar4Leonardo G. Mancillas-Adame5Neri Alejandro Alvarez-Villalobos6Fernando Javier Lavalle-Gonzalez7José Gerardo González-González8Endocrinology Division, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoEndocrinology Division, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoObstetrics and Gynecology Department, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoObstetrics and Gynecology Department, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoEndocrinology Division, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoEndocrinology Division, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoClinical Research Unit, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoEndocrinology Division, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoEndocrinology Division, University Hospital “Dr. José E. González”, School of Medicine, Autonomous University of Nuevo León, Francisco I. Madero and Gonzalitos s/n, 64460 Monterrey, NL, MexicoBackground. Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered. Design and Methods. We conducted a prospective, longitudinal, and controlled study in 23 women with a diagnosis of a complete hydatidiform mole (HM). Results. All participants completed the study. Before HM evacuation mean hCG was markedly higher in the cases than in the control group (P≤0.001). Free testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) were found to be higher in the cases (2.78 ± 1.24 pg/mL and 231.50 ± 127.20 μ/dL) when compared to the control group (1.50 ± 0.75 pg/mL and 133.59 ± 60.69 μ/dL) (P=0.0001 and 0.001), respectively. There was a strong correlation between hCG and free T/total T/DHEA-S concentrations (r=0.78; P≤0.001, r=0.74; P≤0.001, and r=0.71; P≤0.001), respectively. In the cases group 48 hours after HM evacuation, hCG levels were found to be significantly lower when compared to initial levels (P=0.001) and free T and DHEA-S declined significantly (P=0.0002 and 0.009). Conclusion. Before uterus evacuation, hCG, free T, and DHEA-S levels were significantly higher when compared with controls finding a strong correlation between hCG and free T/DHEA-S levels. Forty-eight hours after HM treatment hCG levels declined and the difference was lost. A novel finding of our study is that in cases, besides free T, DHEA-S was also found to be significantly higher and both the ovaries and adrenal glands appear to be the sites of this androgen overproduction.http://dx.doi.org/10.1155/2014/191247 |
| spellingShingle | René Rodríguez-Gutiérrez Jesús Zacarías Villarreal-Pérez Felipe Arturo Morales-Martinez René Rodríguez-Guajardo Gloria González-Saldivar Leonardo G. Mancillas-Adame Neri Alejandro Alvarez-Villalobos Fernando Javier Lavalle-Gonzalez José Gerardo González-González Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study International Journal of Endocrinology |
| title | Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study |
| title_full | Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study |
| title_fullStr | Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study |
| title_full_unstemmed | Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study |
| title_short | Ovarian and Adrenal Androgens and Their Link to High Human Chorionic Gonadotropin Levels: A Prospective Controlled Study |
| title_sort | ovarian and adrenal androgens and their link to high human chorionic gonadotropin levels a prospective controlled study |
| url | http://dx.doi.org/10.1155/2014/191247 |
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