CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp

CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp

Few studies have reported obtaining grass carp resistant to hemorrhagic disease via gene editing in commercial fish. Here, we demonstrate that the expression and activity of grass carp PI4KB (gcPI4KB) are vital for GCRV-I and GCRV-II replication. Given the obvious cytopathic effect (CPE) in the pres...

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Bibliographic Details
Main Authors: Jie Zhang, Liqiang Zhang, Xiaoman Wu, Minhui Tao, Yang Chen, Mingxian Chang
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2025-01-01
Series:Water Biology and Security
Subjects:
PI4KB
GCRV
Viral inclusion bodies
PI4KB F0 juvenile grass carp crispants
CRISPR/Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S2772735124000957
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