Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation

Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation

Abstract Background Functional mitral regurgitation (MR) is a common form of mitral valve dysfunction that often persists even after surgical intervention, requiring reoperation in some cases. To advance our understanding of the pathogenesis of functional MR, it is crucial to characterize the cellul...

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Bibliographic Details
Main Authors: Xiaohu Wang, Mengxia Fu, Weiteng Wang, Songren Shu, Ningning Zhang, Ruojin Zhao, Xiao Chen, Xiumeng Hua, Xin Wang, Wei Feng, Xianqiang Wang, Jiangping Song
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Medicine
Subjects:
ScRNA-seq
Functional mitral regurgitation
Valvular endothelial cell
FABP4
Online Access:https://doi.org/10.1186/s12916-024-03791-4
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