Enhancing the wound healing potential using earthworm clitellum factors and elucidating its molecular mechanism in an in-vitro and earthworm model

Enhancing the wound healing potential using earthworm clitellum factors and elucidating its molecular mechanism in an in-vitro and earthworm model

Abstract Earthworm, Eudrilus eugeniae cannot survive and regenerate without clitellum segments. In regenerating worms, the clitellum’s epithelial and circular muscular layers are reduced to one-third, and longitudinal cell layers to half. In C2C12 cells, Clitellum Factors (CF − 5, 25 and 50%) and Re...

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Main Authors: Kamarajan Rajagopalan, Jackson Durairaj Selvan Christyraj, Johnson Retnaraj Samuel Selvan Christyraj, Meikandan Chandrasekar, Nivedha Balamurugan, Nandha Kumar Suresh, Puja Das, Ashwin Barath Vaidhyalingham, Leela Bharathiraja
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Wound healing
Clitellum factors
C2C12
Wnt3a
VEGF
Cox2
Online Access:https://doi.org/10.1038/s41598-024-79304-3
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