Autophagy and exosome dynamics in Radiation-Induced pulmonary fibrosis: the critical role of TRIB3

Autophagy and exosome dynamics in Radiation-Induced pulmonary fibrosis: the critical role of TRIB3

Abstract Objective Dysregulated autophagy plays a critical role in the pathogenesis of pulmonary fibrosis. The stress protein TRIB3 has been correlated with abnormal autophagy, but its specific contribution to radiation-induced pulmonary fibrosis (RIPF) remains unclear. This study aimed to elucidate...

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Bibliographic Details
Main Authors: Na Li, Wenyue Zhao, Jiale Li, Dengfeng Zhang, Kejun Li, Mengmeng Yang, Xinran Lu, Liqing Du, Chang Xu, Qiang Liu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Respiratory Research
Subjects:
Radiation-induce pulmonary fibrosis
TRIB3
Alveolar epithelial type II cells (AEC II)
Autophagic flux
Exosome
Online Access:https://doi.org/10.1186/s12931-025-03271-0
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