Safety evaluation of ethanol extract from Artocarpus altilis leaves as a herbal medicine candidate: Studies in acute and subchronic toxicity

Safety evaluation of ethanol extract from Artocarpus altilis leaves as a herbal medicine candidate: Studies in acute and subchronic toxicity

Background: Artocarpus altilis is a traditional medicine proven to be efficacious in several pharmacological tests using animal models. However, there have been no reports regarding its safety so far. Therefore, this study aimed to evaluate the toxicity of ethanol extract of A. altilis (EAA) in expe...

Full description

Saved in:

Bibliographic Details
Main Authors:	Fitrya Fitrya, Elfita Elfita, Ferlinahayati, Salma Fayzah Septami, Umi Tsalsa Sabrina, Fatma Sri Wahyuni, Annisa Amriani, Rennie Puspa Novita
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Series:	Phytomedicine Plus
Subjects:	Acute toxicity Artocarpus altilis Ethanol extract Subchronic toxicity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667031324001702
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Decreasing alpha-synuclein aggregation on rotenone-induced adult Zebrafish as Parkinson’s Diseases model by ethanol extraction of Keluwih (Artocarpus camansi) leaves
by: Marisca Evalina Gondokesumo, et al.
Published: (2023-09-01)

<i>In Silico</i> Investigation of γ-Sitosterol Isolated from the Ethanol Extract of <i>Artocarpus camansi</i> Leaves as a Sunscreen Agent
by: Rosnani Nasution, et al.
Published: (2025-01-01)

Utilization of Cempedak (Artocarpus champeden) by Communities in Sabun Village, Central Aitinyo Sub-district, Maybrat Regency, West Papua Province
by: Ariance Juli Ross Nauw, et al.
Published: (2016-01-01)

Clinical impacts of Artocarpus lakoocha agglutinin-binding glycans for prognosis and treatment of cholangiocarcinoma
by: Phisit Sintusen, et al.
Published: (2025-01-01)

Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats
by: Sudha Sairam, et al.
Published: (2014-01-01)

Mitigating Mercury Chloride-Induced Spleen Toxicity in Wistar Rats: The Efficacy of Newbouldia laevis Ethanol Extract
by: Calmday-Ombo D, et al.
Published: (2025-01-01)

Establishment Methods and Application Evaluation of Animal Models in Reproductive Toxicology Research
by: HUANG Dongyan, et al.
Published: (2024-10-01)

Larvicidal Effect of Breadfruit (Artocarpus altilis) Flower Extract Against Aedes aegypti
by: Ni Wayan Winianti, et al.
Published: (2024-09-01)

Physicochemical Characteristics of Breadfruit (Artocarpus altilis) Starch Based on Starch Preparation and Modification Methods
by: Santi Noviasari, et al.
Published: (2024-11-01)

Acute toxicological and behavioural effects of perfluorohexanoic acid (PFHxA) in the model nematode, Caenorhabditis elegans
by: Tanmoy Sana, et al.
Published: (2025-04-01)

Toxicity evaluation of herbicides used in sugarcane crops to Zebrafish (Danio rerio)
by: Gabrielli Aparecida Sanches Tesolin, et al.
Published: (2014-01-01)

Revealing Sarcophyton extract's alleviating potential against gentamicin-induced renal and testicular toxicity in rat model
by: Nada S. Badr, et al.
Published: (2025-02-01)

Toxicity of Common Indoor Household Insecticides Registered in Florida
by: Frederick M. Fishel
Published: (2019-09-01)

Toxicity of Common Indoor Household Insecticides Registered in Florida
by: Frederick M. Fishel
Published: (2019-09-01)

Toxic effects and mechanisms of nanoplastics and sulfonamide antibiotics on Scenedesmus obliquus
by: Jianyuan Yang, et al.
Published: (2025-01-01)

Favorable Nonclinical Safety Profile of RSVpreF Bivalent Vaccine in Rats and Rabbits
by: Jun Zhou, et al.
Published: (2024-12-01)

Predicting High-Grade Acute Urinary Toxicity and Lower Gastrointestinal Toxicity After Postoperative Volumetric Modulated Arc Therapy for Cervical and Endometrial Cancer Using a Normal Tissue Complication Probability Model
by: Tianyu Yang, et al.
Published: (2025-01-01)

Evaluating the toxicity of sea-dumped conventional and chemical munition degradation products to fish and human cells using a combination of cell viability assays
by: João Barbosa, et al.
Published: (2025-02-01)

New Paraquat Requirements
by: Frederick M. Fishel
Published: (2018-11-01)

Mercury and its Associated Impacts on Environment and Human Health: A Review
by: Alex, Saturday
Published: (2018)

New Paraquat Requirements
by: Frederick M. Fishel
Published: (2018-11-01)

Common Toxic Plants for Florida Horse Owners
by: Alyssa Schortinghouse, et al.
Published: (2023-02-01)

Urdu Toxic Comment Classification With PURUTT Corpus Development
by: Hafiz Hassaan Saeed, et al.
Published: (2025-01-01)

Toxicity of Low-dose Graphene Oxide Nanoparticles in an in-vivo Wild Type of Caenorhabditis elegans Model
by: Ming-Hsien Tsai, et al.
Published: (2020-12-01)

Phthalates toxicity in vivo to rats, mice, birds, and fish: A thematic scoping review
by: Mohammad Shah Alam, et al.
Published: (2025-01-01)

Toxicity of Per- and Polyfluoroalkyl Substances and Their Substitutes to Terrestrial and Aquatic Invertebrates—A Review
by: Jiaxin Zhang, et al.
Published: (2025-01-01)

Maternal exposure to tris (2-butoxyethyl) phosphate induces F0 female reproductive toxicity and offspring developmental toxicity in zebrafish
by: Anqi Dong, et al.
Published: (2025-01-01)

Water and sediment quality assessment at São Lourenço River-SP
by: Angélica Megda da Silva, et al.
Published: (2014-01-01)

Phytotoxicity of aluminum ions
by: O. V. Yakovleva
Published: (2019-01-01)

Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs
by: Alana C. Costa, et al.
Published: (2025-06-01)

Outcomes of the toxic hepatites caused by alcohol surrogates
by: I. Yu. Pirogova, et al.
Published: (2013-12-01)

Pathology of single dose cadmium toxicity and investigations of protective effect of simultaneous chlorpromazine administrations in rats
by: Tuna Erdem, et al.

Evaluation of Acute and Sub-Chronic Toxicity of Lactobacillus rhamnosus GG in Sprague-Dawley Rats
by: Vedam Venkata Kanthi Vaishnavi, et al.
Published: (2024-12-01)

The differentiation state of small intestinal organoid models influences prediction of drug-induced toxicity
by: Jessica A. Klein, et al.
Published: (2025-01-01)

Aluminum resistance of malting barley
by: O. V. Yakovleva
Published: (2021-12-01)

Equations for estimating binary mixture toxicity: Methyl-2-chloroacetoacetate-containing combinations
by: Douglas A. Dawson, et al.
Published: (2025-06-01)

Nanobubble Ozone Stored in Hyaluronic Acid-Decorated Liposome Solutions: Inactivating Antibiotic-Resistant Bacteria and Genotoxicity, Sub-Acute and Sub-Chronic Toxicity Tests
by: Erkan Alkan P, et al.
Published: (2025-01-01)

A systematic review of exposure to toxic elements and neurocognitive development in children
by: Tingyi Guo, et al.
Published: (2025-02-01)

Ecotoxicological evaluation in aquaculture in state park Serra do Mar-SP, Nucleo Itariru
by: Bruno Galvão de Campos, et al.
Published: (2014-01-01)

Understanding the impact of triazoles on female fertility and embryo development: Mechanisms and implications
by: Sonal Sharma, et al.
Published: (2025-06-01)