The mechanisms and application prospects of exosomes in acute myocardial infarction
Acute myocardial infarction (AMI) is a significant cause of death in cardiovascular diseases and an important topic in forensic pathology. It triggers various cellular pathological changes, leading to ventricular remodeling, changes in cardiac function, and, in severe cases, death. Current biomarker...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Extracellular Vesicle |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041725000095 |
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| author | Peng Zhou Jia Zhang Leilei Zhang Jiangwei Yan Chen Fang |
| author_facet | Peng Zhou Jia Zhang Leilei Zhang Jiangwei Yan Chen Fang |
| author_sort | Peng Zhou |
| collection | DOAJ |
| description | Acute myocardial infarction (AMI) is a significant cause of death in cardiovascular diseases and an important topic in forensic pathology. It triggers various cellular pathological changes, leading to ventricular remodeling, changes in cardiac function, and, in severe cases, death. Current biomarkers for AMI lack specificity and can be influenced by various factors, making them challenging for diagnosis and differentiation. Exosomes, small vesicles with a lipid bilayer membrane, have emerged as potential biomarkers and therapeutic targets for AMI. They play a crucial role in intercellular cargo transport and communication. Exosomes play a dual role in cellular processes, exhibiting protective mechanisms under normal conditions while also contributing to disease progression in pathological contexts. This paper summarizes the mechanisms, research strategies, and application prospects of exosomes in AMI, providing insights for forensic investigations. |
| format | Article |
| id | doaj-art-0816e2bf6e9a4deaa9a448081f6210b7 |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-0816e2bf6e9a4deaa9a448081f6210b72025-08-20T03:46:58ZengElsevierExtracellular Vesicle2773-04172025-06-01510007310.1016/j.vesic.2025.100073The mechanisms and application prospects of exosomes in acute myocardial infarctionPeng Zhou0Jia Zhang1Leilei Zhang2Jiangwei Yan3Chen Fang4Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, PR China; Department of Forensic Medicine, School of Clinical and Basic Medical Sciences, Shandong First Medical University& Shandong Academy of Medical Sciences, Jinan, 250117, PR ChinaShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, PR China; Department of Forensic Medicine, School of Clinical and Basic Medical Sciences, Shandong First Medical University& Shandong Academy of Medical Sciences, Jinan, 250117, PR ChinaPhysical Evidence Appraisal Center of Shandong Provincial Public Security Department, Jinan, 250001, PR ChinaDepartment of Forensic Medicine, School of Clinical and Basic Medical Sciences, Shandong First Medical University& Shandong Academy of Medical Sciences, Jinan, 250117, PR China; Shanxi Medical University, Taiyuan, 030001, PR China; Corresponding author. Shanxi Medical University, Taiyuan, 030001, PR China.Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, PR China; Department of Forensic Medicine, School of Clinical and Basic Medical Sciences, Shandong First Medical University& Shandong Academy of Medical Sciences, Jinan, 250117, PR China; Corresponding author. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, PR China.Acute myocardial infarction (AMI) is a significant cause of death in cardiovascular diseases and an important topic in forensic pathology. It triggers various cellular pathological changes, leading to ventricular remodeling, changes in cardiac function, and, in severe cases, death. Current biomarkers for AMI lack specificity and can be influenced by various factors, making them challenging for diagnosis and differentiation. Exosomes, small vesicles with a lipid bilayer membrane, have emerged as potential biomarkers and therapeutic targets for AMI. They play a crucial role in intercellular cargo transport and communication. Exosomes play a dual role in cellular processes, exhibiting protective mechanisms under normal conditions while also contributing to disease progression in pathological contexts. This paper summarizes the mechanisms, research strategies, and application prospects of exosomes in AMI, providing insights for forensic investigations.http://www.sciencedirect.com/science/article/pii/S2773041725000095ExosomesAcute myocardial infarctionLipids proteinmiRNA |
| spellingShingle | Peng Zhou Jia Zhang Leilei Zhang Jiangwei Yan Chen Fang The mechanisms and application prospects of exosomes in acute myocardial infarction Extracellular Vesicle Exosomes Acute myocardial infarction Lipids protein miRNA |
| title | The mechanisms and application prospects of exosomes in acute myocardial infarction |
| title_full | The mechanisms and application prospects of exosomes in acute myocardial infarction |
| title_fullStr | The mechanisms and application prospects of exosomes in acute myocardial infarction |
| title_full_unstemmed | The mechanisms and application prospects of exosomes in acute myocardial infarction |
| title_short | The mechanisms and application prospects of exosomes in acute myocardial infarction |
| title_sort | mechanisms and application prospects of exosomes in acute myocardial infarction |
| topic | Exosomes Acute myocardial infarction Lipids protein miRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2773041725000095 |
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