Selection forces underlying aneuploidy patterns in cancer
Aneuploidy, the presence of an aberrant number of chromosomes, has been associated with tumorigenesis for over a century. More recently, advances in karyotyping techniques have revealed its high prevalence in cancer: About 90% of solid tumors and 50–70% of hematopoietic cancers exhibit chromosome ga...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Molecular & Cellular Oncology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/23723556.2024.2369388 |
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| author | Tamara C. Klockner Christopher S. Campbell |
| author_facet | Tamara C. Klockner Christopher S. Campbell |
| author_sort | Tamara C. Klockner |
| collection | DOAJ |
| description | Aneuploidy, the presence of an aberrant number of chromosomes, has been associated with tumorigenesis for over a century. More recently, advances in karyotyping techniques have revealed its high prevalence in cancer: About 90% of solid tumors and 50–70% of hematopoietic cancers exhibit chromosome gains or losses. When analyzed at the level of specific chromosomes, there are strong patterns that are observed in cancer karyotypes both pan-cancer and for specific cancer types. These specific aneuploidy patterns correlate strongly with outcomes for tumor initiation, progression, metastasis formation, immune evasion and resistance to therapeutic treatment. Despite their prominence, understanding the basis underlying aneuploidy patterns in cancer has been challenging. Advances in genetic engineering and bioinformatic analyses now offer insights into the genetic determinants of aneuploidy pattern selection. Overall, there is substantial evidence that expression changes of particular genes can act as the positive selective forces for adaptation through aneuploidy. Recent findings suggest that multiple genes contribute to the selection of specific aneuploid chromosomes in cancer; however, further research is necessary to identify the most impactful driver genes. Determining the genetic basis and accompanying vulnerabilities of specific aneuploidy patterns is an essential step in selectively targeting these hallmarks of tumors. |
| format | Article |
| id | doaj-art-07f5c481301b45e98d982f4f334e4056 |
| institution | Kabale University |
| issn | 2372-3556 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj-art-07f5c481301b45e98d982f4f334e40562024-12-13T07:00:18ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562024-12-0111110.1080/23723556.2024.2369388Selection forces underlying aneuploidy patterns in cancerTamara C. Klockner0Christopher S. Campbell1Max Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, AustriaMax Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, AustriaAneuploidy, the presence of an aberrant number of chromosomes, has been associated with tumorigenesis for over a century. More recently, advances in karyotyping techniques have revealed its high prevalence in cancer: About 90% of solid tumors and 50–70% of hematopoietic cancers exhibit chromosome gains or losses. When analyzed at the level of specific chromosomes, there are strong patterns that are observed in cancer karyotypes both pan-cancer and for specific cancer types. These specific aneuploidy patterns correlate strongly with outcomes for tumor initiation, progression, metastasis formation, immune evasion and resistance to therapeutic treatment. Despite their prominence, understanding the basis underlying aneuploidy patterns in cancer has been challenging. Advances in genetic engineering and bioinformatic analyses now offer insights into the genetic determinants of aneuploidy pattern selection. Overall, there is substantial evidence that expression changes of particular genes can act as the positive selective forces for adaptation through aneuploidy. Recent findings suggest that multiple genes contribute to the selection of specific aneuploid chromosomes in cancer; however, further research is necessary to identify the most impactful driver genes. Determining the genetic basis and accompanying vulnerabilities of specific aneuploidy patterns is an essential step in selectively targeting these hallmarks of tumors.https://www.tandfonline.com/doi/10.1080/23723556.2024.2369388Aneuploidy patternscancerselection forcesdriver genes |
| spellingShingle | Tamara C. Klockner Christopher S. Campbell Selection forces underlying aneuploidy patterns in cancer Molecular & Cellular Oncology Aneuploidy patterns cancer selection forces driver genes |
| title | Selection forces underlying aneuploidy patterns in cancer |
| title_full | Selection forces underlying aneuploidy patterns in cancer |
| title_fullStr | Selection forces underlying aneuploidy patterns in cancer |
| title_full_unstemmed | Selection forces underlying aneuploidy patterns in cancer |
| title_short | Selection forces underlying aneuploidy patterns in cancer |
| title_sort | selection forces underlying aneuploidy patterns in cancer |
| topic | Aneuploidy patterns cancer selection forces driver genes |
| url | https://www.tandfonline.com/doi/10.1080/23723556.2024.2369388 |
| work_keys_str_mv | AT tamaracklockner selectionforcesunderlyinganeuploidypatternsincancer AT christopherscampbell selectionforcesunderlyinganeuploidypatternsincancer |