NetStart 2.0: prediction of eukaryotic translation initiation sites using a protein language model

NetStart 2.0: prediction of eukaryotic translation initiation sites using a protein language model

Abstract Background Accurate identification of translation initiation sites is essential for the proper translation of mRNA into functional proteins. In eukaryotes, the choice of the translation initiation site is influenced by multiple factors, including its proximity to the 5 $$^\prime $$ end and...

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Bibliographic Details
Main Authors: Line Sandvad Nielsen, Anders Gorm Pedersen, Ole Winther, Henrik Nielsen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Bioinformatics
Subjects:
Protein language models
Translation initiation sites
Start codons
Deep learning
“Protein-ness”
Coding potential
Online Access:https://doi.org/10.1186/s12859-025-06220-2
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